DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_APCC_DBOX_1

Location: 185:193

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9951

ASA_SCORE: 94.4889

COIL: 0.8307

CONS_SCORE: 0.4652

DSS_SCORE: 0.3766

HELIX: 0.0484

FCONS_SCORE: 1.1223

RIG_SCORE: 0.7847

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T190A	TCGA-28-1751	GBM	TCGA	PRHELTEIS	DEG_APCC_DBOX_1	0.7139
p.T190A	DO13743	GBM	ICGC	PRHELTEIS	DEG_APCC_DBOX_1	0.7139
p.P185Q	TCGA-EE-A181	SKCM	TCGA	PRHELTEIS	DEG_APCC_DBOX_1	0.5924
p.P185Q	DO37444	SKCM	ICGC	PRHELTEIS	DEG_APCC_DBOX_1	0.5924
p.Q200K	TCGA-FS-A1ZG	SKCM	TCGA	PRHELTEIS	DEG_APCC_DBOX_1	0.1389
p.Q200K	DO37523	SKCM	ICGC	PRHELTEIS	DEG_APCC_DBOX_1	0.1389
p.E179D	TCGA-FS-A1ZZ	SKCM	TCGA	PRHELTEIS	DEG_APCC_DBOX_1	0.1667
p.E179D	DO37412	SKCM	ICGC	PRHELTEIS	DEG_APCC_DBOX_1	0.1667
p.G202W	DO231584	NBL	ICGC	PRHELTEIS	DEG_APCC_DBOX_1	0.0833
p.I182V	SIDM01126	Small Cell Lung Carcinoma	GDSC	PRHELTEIS	DEG_APCC_DBOX_1	0.25
p.I182V	ACH-001599	Lung Cancer	CCLE	PRHELTEIS	DEG_APCC_DBOX_1	0.25
p.I182V	NCI-H64	lung	COSMIC	PRHELTEIS	DEG_APCC_DBOX_1	0.25
p.H187Y	SIDM00789	Colorectal Carcinoma	GDSC	PRHELTEIS	DEG_APCC_DBOX_1	0.6118
p.H187Y	ACH-000997	Colon/Colorectal Cancer	CCLE	PRHELTEIS	DEG_APCC_DBOX_1	0.6118
p.H187Y	HCT-15	large_intestine	COSMIC	PRHELTEIS	DEG_APCC_DBOX_1	0.6118
p.S201F	SIDM01699	Chondrosarcoma	GDSC	PRHELTEIS	DEG_APCC_DBOX_1	0.5556
p.S201F	ACH-000224	Non-Cancerous	CCLE	PRHELTEIS	DEG_APCC_DBOX_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_APCC_DBOX_1	185:193	PRHELTEIS	APC,CDC20,FZR1	0.9951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons