DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_SCF_FBW7_1

Location: 5007:5013

E3 ligase: FBXW7

DEGRON score: 0.9601

ASA_SCORE: 74.5143

COIL: 0.5793

CONS_SCORE: 0.5152

DSS_SCORE: 0.4729

HELIX: 0.0516

FCONS_SCORE: 0.993

RIG_SCORE: 0.7503

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N5006D	TCGA-AP-A1DK	UCEC	TCGA	LETPEIS	DEG_SCF_FBW7_1	0.3056
p.N5006D	DO42033	UCEC	ICGC	LETPEIS	DEG_SCF_FBW7_1	0.3056
p.E5008Q	TCGA-BA-5152	HNSC	TCGA	LETPEIS	DEG_SCF_FBW7_1	0.5633
p.E5008Q	DO14393	HNSC	ICGC	LETPEIS	DEG_SCF_FBW7_1	0.5633
p.E5008K	TCGA-VQ-A8P5	STAD	TCGA	LETPEIS	DEG_SCF_FBW7_1	0.591
p.E5008K	DO51763	STAD	ICGC	LETPEIS	DEG_SCF_FBW7_1	0.591
p.G5016S	DO223014	ESCA	ICGC	LETPEIS	DEG_SCF_FBW7_1	0.25
p.G5016S	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	LETPEIS	DEG_SCF_FBW7_1	0.25
p.G5016S	ACH-000447	Lung Cancer	CCLE	LETPEIS	DEG_SCF_FBW7_1	0.25
p.G5016S	NCI-H2228	lung	COSMIC	LETPEIS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_SCF_FBW7_1	5007:5013	LETPEIS	FBXW7	0.9601	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons