DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_SCF_FBW7_2

Location: 543:549

E3 ligase: FBXW7

DEGRON score: 0.995

ASA_SCORE: 82.6857

COIL: 0.6867

CONS_SCORE: 0.4408

DSS_SCORE: 0.5402

HELIX: 0.072

FCONS_SCORE: 1.1995

RIG_SCORE: 0.7479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T553I	TCGA-46-6025	LUSC	TCGA	IETPNLE	DEG_SCF_FBW7_2	0.6667
p.T553I	DO26644	LUSC	ICGC	IETPNLE	DEG_SCF_FBW7_2	0.6667
p.E549D	TCGA-A5-A1OF	UCEC	TCGA	IETPNLE	DEG_SCF_FBW7_2	0.6758
p.E549D	DO42568	UCEC	ICGC	IETPNLE	DEG_SCF_FBW7_2	0.6758
p.N547S	TCGA-AO-A128	BRCA	TCGA	IETPNLE	DEG_SCF_FBW7_2	0.5958
p.N547S	DO5326	BRCA	ICGC	IETPNLE	DEG_SCF_FBW7_2	0.5958
p.L557I	TCGA-DU-6392	LGG	TCGA	IETPNLE	DEG_SCF_FBW7_2	0.1111
p.L557I	DO22237	LGG	ICGC	IETPNLE	DEG_SCF_FBW7_2	0.1111
p.L548P	TCGA-RD-A8N1	STAD	TCGA	IETPNLE	DEG_SCF_FBW7_2	0.6471
p.L548P	DO50136	STAD	ICGC	IETPNLE	DEG_SCF_FBW7_2	0.6471
p.I543T	DO233843	GACA	ICGC	IETPNLE	DEG_SCF_FBW7_2	0.7078
p.D542E	DO229019	LICA	ICGC	IETPNLE	DEG_SCF_FBW7_2	0.3056
p.K537R	DO23232	LINC	ICGC	IETPNLE	DEG_SCF_FBW7_2	0.6111
p.R556G	ACH-000919	Gastric Cancer	CCLE	IETPNLE	DEG_SCF_FBW7_2	0.1389
p.R556G	IM-95	stomach	COSMIC	IETPNLE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_SCF_FBW7_2	543:549	IETPNLE	FBXW7	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons