DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_COP1_1

Location: 3117:3125

E3 ligase: COP1

DEGRON score: 0.9058

ASA_SCORE: 77.6778

COIL: 0.5201

CONS_SCORE: 0.4345

DSS_SCORE: 0.4846

HELIX: 0.0148

FCONS_SCORE: 0.9934

RIG_SCORE: 0.7515

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D3119N	TCGA-75-7027	LUAD	TCGA	EGDMKVPDV	DEG_COP1_1	0.6932
p.D3119N	DO24811	LUAD	ICGC	EGDMKVPDV	DEG_COP1_1	0.6932
p.I3134V	TCGA-AX-A06F	UCEC	TCGA	EGDMKVPDV	DEG_COP1_1	0.0833
p.I3134V	DO41752	UCEC	ICGC	EGDMKVPDV	DEG_COP1_1	0.0833
p.I3134V	SIDM00333	Endometrial Carcinoma	GDSC	EGDMKVPDV	DEG_COP1_1	0.0833
p.I3134V	ACH-000988	Endometrial/Uterine Cancer	CCLE	EGDMKVPDV	DEG_COP1_1	0.0833
p.I3134V	MFE-319	endometrium	COSMIC	EGDMKVPDV	DEG_COP1_1	0.0833
p.V3125M	TCGA-B5-A1MW	UCEC	TCGA	EGDMKVPDV	DEG_COP1_1	0.6097
p.V3125M	TCGA-BA-A6DF	HNSC	TCGA	EGDMKVPDV	DEG_COP1_1	0.6097
p.V3125M	DO44442	HNSC	ICGC	EGDMKVPDV	DEG_COP1_1	0.6097
p.V3125M	DO42913	UCEC	ICGC	EGDMKVPDV	DEG_COP1_1	0.6097
p.K3115E	TCGA-CA-6717	COAD	TCGA	EGDMKVPDV	DEG_COP1_1	0.2778
p.K3115E	DO8264	COAD	ICGC	EGDMKVPDV	DEG_COP1_1	0.2778
p.M3120I	TCGA-CQ-6221	HNSC	TCGA	EGDMKVPDV	DEG_COP1_1	0.6507
p.M3120I	TCGA-ZD-A8I3	CHOL	TCGA	EGDMKVPDV	DEG_COP1_1	0.6507
p.M3120I	DO14622	HNSC	ICGC	EGDMKVPDV	DEG_COP1_1	0.6507
p.P3123S	TCGA-D3-A3ML	SKCM	TCGA	EGDMKVPDV	DEG_COP1_1	0.6752
p.P3123S	DO47413	SKCM	ICGC	EGDMKVPDV	DEG_COP1_1	0.6752
p.V3125L	TCGA-EC-A1NJ	UCEC	TCGA	EGDMKVPDV	DEG_COP1_1	0.5654
p.V3125L	DO40855	UCEC	ICGC	EGDMKVPDV	DEG_COP1_1	0.5654
p.V3125L	ACH-000261	Lung Cancer	CCLE	EGDMKVPDV	DEG_COP1_1	0.5654
p.I3134M	TCGA-QS-A5YQ	UCEC	TCGA	EGDMKVPDV	DEG_COP1_1	0.0833
p.I3134M	DO49073	UCEC	ICGC	EGDMKVPDV	DEG_COP1_1	0.0833
p.M3120T	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	EGDMKVPDV	DEG_COP1_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	3117:3125	EGDMKVPDV	COP1	0.9058	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons