DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_COP1_1

Location: 844:852

E3 ligase: COP1

DEGRON score: 0.9855

ASA_SCORE: 74.1

COIL: 0.4217

CONS_SCORE: 0.5301

DSS_SCORE: 0.3906

HELIX: 0.0213

FCONS_SCORE: 1.1917

RIG_SCORE: 0.8091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E853Q	TCGA-37-A5EL	LUSC	TCGA	ESEIKVPDV	DEG_COP1_1	0.3056
p.E853Q	DO223718	LUSC	ICGC	ESEIKVPDV	DEG_COP1_1	0.3056
p.K855E	TCGA-EB-A6QZ	SKCM	TCGA	ESEIKVPDV	DEG_COP1_1	0.6944
p.K855E	DO48626	SKCM	ICGC	ESEIKVPDV	DEG_COP1_1	0.6944
p.A857T	TCGA-SW-A7EA	STAD	TCGA	ESEIKVPDV	DEG_COP1_1	0.1944
p.A857T	DO51749	STAD	ICGC	ESEIKVPDV	DEG_COP1_1	0.1944
p.V838I	DO223504	CLLE	ICGC	ESEIKVPDV	DEG_COP1_1	0.1667
p.K842T	DO233921	GACA	ICGC	ESEIKVPDV	DEG_COP1_1	0.2778
p.D837Y	DO36556	READ	ICGC	ESEIKVPDV	DEG_COP1_1	0.1389
p.L854I	SIDM00683	Prostate Carcinoma	GDSC	ESEIKVPDV	DEG_COP1_1	0.2778
p.L854I	ACH-000977	lymph_node	CCLE	ESEIKVPDV	DEG_COP1_1	0.2778
p.D862E	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	ESEIKVPDV	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	844:852	ESEIKVPDV	COP1	0.9855	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons