DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_COP1_1

Location: 1093:1101

E3 ligase: COP1

DEGRON score: 0.9137

ASA_SCORE: 77.3444

COIL: 0.5366

CONS_SCORE: 0.4708

DSS_SCORE: 0.5077

HELIX: 0.018

FCONS_SCORE: 0.9453

RIG_SCORE: 0.7467

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1090S	TCGA-67-3772	LUAD	TCGA	EGEMQVPDV	DEG_COP1_1	0.25
p.P1090S	DO23729	LUAD	ICGC	EGEMQVPDV	DEG_COP1_1	0.25
p.D1109H	TCGA-94-7943	LUSC	TCGA	EGEMQVPDV	DEG_COP1_1	0.1111
p.D1109H	DO26475	LUSC	ICGC	EGEMQVPDV	DEG_COP1_1	0.1111
p.I1103T	TCGA-BR-7723	STAD	TCGA	EGEMQVPDV	DEG_COP1_1	0.2778
p.I1103T	DO38875	STAD	ICGC	EGEMQVPDV	DEG_COP1_1	0.2778
p.S1088C	TCGA-CG-4440	STAD	TCGA	EGEMQVPDV	DEG_COP1_1	0.6389
p.S1088C	DO38855	STAD	ICGC	EGEMQVPDV	DEG_COP1_1	0.6389
p.D1109N	TCGA-MV-A51V	BLCA	TCGA	EGEMQVPDV	DEG_COP1_1	0.1111
p.D1109N	DO474	BLCA	ICGC	EGEMQVPDV	DEG_COP1_1	0.1111
p.D1102G	DO234459	ESAD	ICGC	EGEMQVPDV	DEG_COP1_1	0.3056
p.D1109V	DO229505	LAML	ICGC	EGEMQVPDV	DEG_COP1_1	0.1111
p.V1098F	DO230659	LAML	ICGC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	DO231140	LAML	ICGC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	DO229038	LICA	ICGC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	DO229047	LICA	ICGC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00570	Gastric Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00614	Hepatocellular Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM01197	Colorectal Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00565	Oral Cavity Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00544	Neuroblastoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM01145	Gastric Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00417	Plasma Cell Myeloma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00526	Chronic Myelogenous Leukemia	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00502	B-Lymphoblastic Leukemia	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00280	Gastric Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00807	Bladder Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00217	Colorectal Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00996	Thyroid Gland Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00233	T-Lymphoblastic Leukemia	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00591	Oral Cavity Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM01372	Pancreatic Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM01612	Endometrial Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM00168	Head and Neck Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM01393	Gastric Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM01472	Hepatocellular Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM01347	Ovarian Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM01442	Glioma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.V1098F	SIDM01343	Gastric Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7068
p.P1090Q	DO229031	LICA	ICGC	EGEMQVPDV	DEG_COP1_1	0.25
p.V1098I	SIDM00371	Pancreatic Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.7076
p.V1098I	SUIT-2	pancreas	COSMIC	EGEMQVPDV	DEG_COP1_1	0.7076
p.P1090L	SIDM00403	T-Lymphoblastic Leukemia	GDSC	EGEMQVPDV	DEG_COP1_1	0.25
p.P1090L	ACH-000636	Leukemia	CCLE	EGEMQVPDV	DEG_COP1_1	0.25
p.P1090L	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	EGEMQVPDV	DEG_COP1_1	0.25
p.G1083R	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.0556
p.G1083R	SIDM00855	Other Sarcomas	GDSC	EGEMQVPDV	DEG_COP1_1	0.0556
p.G1083R	ACH-000375	Kidney Cancer	CCLE	EGEMQVPDV	DEG_COP1_1	0.0556
p.G1083R	ACH-000789	Lung Cancer	CCLE	EGEMQVPDV	DEG_COP1_1	0.0556
p.G1083R	G-402	soft_tissue	COSMIC	EGEMQVPDV	DEG_COP1_1	0.0556
p.G1083R	NCI-H810	lung	COSMIC	EGEMQVPDV	DEG_COP1_1	0.0556
p.G1105S	SIDM00282	Colorectal Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	0.2222
p.G1105S	ACH-000998	Colon/Colorectal Cancer	CCLE	EGEMQVPDV	DEG_COP1_1	0.2222
p.G1105S	CW-2	large_intestine	COSMIC	EGEMQVPDV	DEG_COP1_1	0.2222
p.D1100N	ACH-000923	Lymphoma	CCLE	EGEMQVPDV	DEG_COP1_1	0.6932

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EGEMQVPDV

Degron related mutations and impact score

Drug responses associated with AHNAK mutations

All proteins holding degron of EGEMQVPDV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1093:1101	EGEMQVPDV	COP1	0.9137	More...