DegronMD

Uniprot ID: Q5VZE5

Source protein: N-alpha-acetyltransferase 35, NatC auxiliary subunit

Source gene: NAA35

Class: CBL_PTK

Location: 642:650

E3 ligase: CBL

DEGRON score: 0.8273

ASA_SCORE: 81.4

COIL: 0.8328

CONS_SCORE: 0.2097

DSS_SCORE: 0.4783

HELIX: 0.1396

FCONS_SCORE: 0.5947

RIG_SCORE: 0.6537

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S647N	TCGA-DF-A2KU	UCEC	TCGA	DLNKYSPPP	CBL_PTK	0.818
p.S647N	DO223286	UCEC	ICGC	DLNKYSPPP	CBL_PTK	0.818
p.Y646S	DO225370	BRCA	ICGC	DLNKYSPPP	CBL_PTK	0.712
p.Y646C	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	DLNKYSPPP	CBL_PTK	0.7087
p.Y646C	ACH-002263	Esophageal Cancer	CCLE	DLNKYSPPP	CBL_PTK	0.7087
p.Y646C	KYSE-220	oesophagus	COSMIC	DLNKYSPPP	CBL_PTK	0.7087
p.K638N	TCGA-EE-A29Q	SKCM	TCGA	DLNKYSPPP	CBL_PTK	0.6667
p.K638N	TCGA-EE-A2GN	SKCM	TCGA	DLNKYSPPP	CBL_PTK	0.6667
p.K638N	DO37896	SKCM	ICGC	DLNKYSPPP	CBL_PTK	0.6667
p.K638N	DO37866	SKCM	ICGC	DLNKYSPPP	CBL_PTK	0.6667
p.S641C	TCGA-63-5131	LUSC	TCGA	DLNKYSPPP	CBL_PTK	0.3056
p.S641C	DO26898	LUSC	ICGC	DLNKYSPPP	CBL_PTK	0.3056
p.Q651E	TCGA-IR-A3LA	CESC	TCGA	DLNKYSPPP	CBL_PTK	0.3056
p.Q651E	DO44377	CESC	ICGC	DLNKYSPPP	CBL_PTK	0.3056
p.Q651H	DO229009	LICA	ICGC	DLNKYSPPP	CBL_PTK	0.3056
p.P653H	TCGA-EE-A3AD	SKCM	TCGA	DLNKYSPPP	CBL_PTK	0.25
p.P653H	DO37707	SKCM	ICGC	DLNKYSPPP	CBL_PTK	0.25
p.P653S	SIDM01117	Small Cell Lung Carcinoma	GDSC	DLNKYSPPP	CBL_PTK	0.25
p.P653S	SIDM01525	Acute Myeloid Leukemia	GDSC	DLNKYSPPP	CBL_PTK	0.25
p.Q636H	DO228978	LICA	ICGC	DLNKYSPPP	CBL_PTK	0.1667
p.V657L	DO229036	LICA	ICGC	DLNKYSPPP	CBL_PTK	0.1389
p.Y634C	TCGA-F7-A624	HNSC	TCGA	DLNKYSPPP	CBL_PTK	0.1111
p.Y634C	DO44440	HNSC	ICGC	DLNKYSPPP	CBL_PTK	0.1111
p.A658T	SIDM00118	Colorectal Carcinoma	GDSC	DLNKYSPPP	CBL_PTK	0.1111
p.A658T	ACH-001081	Colon/Colorectal Cancer	CCLE	DLNKYSPPP	CBL_PTK	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZE5	N-alpha-acetyltransferase 35, NatC auxiliary subunit	CBL_PTK	642:650	DLNKYSPPP	CBL	0.8273	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons