DegronMD - Q5VZE5(NAA35)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M18V	TCGA-50-5044	LUAD	TCGA	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.3056
p.M18V	DO25584	LUAD	ICGC	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.3056
p.S641C	TCGA-63-5131	LUSC	TCGA	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.3056
p.S641C	DO26898	LUSC	ICGC	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.3056
p.H633Y	TCGA-AX-A1CE	UCEC	TCGA	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.0833
p.H633Y	DO42280	UCEC	ICGC	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.0833
p.E23Q	TCGA-CR-6484	HNSC	TCGA	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.1667
p.E23Q	DO15206	HNSC	ICGC	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.1667
p.E20D	TCGA-D1-A16X	UCEC	TCGA	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.25
p.E20D	DO41799	UCEC	ICGC	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.25
p.S647N	TCGA-DF-A2KU	UCEC	TCGA	DLNKYSPPP	CBL_PTK	642:650	Mutation altering degron motif	0.818
p.S647N	DO223286	UCEC	ICGC	DLNKYSPPP	CBL_PTK	642:650	Mutation altering degron motif	0.818
p.K638N	TCGA-EE-A29Q	SKCM	TCGA	DLNKYSPPP	CBL_PTK	642:650	Mutation blocking ubiquitination signal	0.6667
p.K638N	TCGA-EE-A2GN	SKCM	TCGA	DLNKYSPPP	CBL_PTK	642:650	Mutation blocking ubiquitination signal	0.6667
p.K638N	DO37896	SKCM	ICGC	DLNKYSPPP	CBL_PTK	642:650	Mutation blocking ubiquitination signal	0.6667
p.K638N	DO37866	SKCM	ICGC	DLNKYSPPP	CBL_PTK	642:650	Mutation blocking ubiquitination signal	0.6667
p.P653H	TCGA-EE-A3AD	SKCM	TCGA	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.25
p.P653H	DO37707	SKCM	ICGC	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.25
p.K21T	TCGA-EO-A22R	UCEC	TCGA	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation blocking ubiquitination signal	0.6667
p.K21T	DO42713	UCEC	ICGC	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation blocking ubiquitination signal	0.6667
p.Y634C	TCGA-F7-A624	HNSC	TCGA	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.1111
p.Y634C	DO44440	HNSC	ICGC	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.1111
p.Q651E	TCGA-IR-A3LA	CESC	TCGA	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.3056
p.Q651E	DO44377	CESC	ICGC	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.3056
p.Y646S	DO225370	BRCA	ICGC	DLNKYSPPP	CBL_PTK	642:650	Mutation altering degron motif	0.712
p.D8H	DO223012	ESCA	ICGC	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.25
p.Q636H	DO228978	LICA	ICGC	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.1667
p.W14L	DO229019	LICA	ICGC	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation altering degron motif	0.5904
p.V657L	DO229036	LICA	ICGC	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.1389
p.D10Y	DO229050	LICA	ICGC	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.3056
p.Q651H	DO229009	LICA	ICGC	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.3056
p.N26D	DO45049	LINC	ICGC	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.0833
p.K4N	DO50804	LIRI	ICGC	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation substituting flanking lysine	0.25
p.P653S	SIDM01117	Small Cell Lung Carcinoma	GDSC	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.25
p.P653S	SIDM01525	Acute Myeloid Leukemia	GDSC	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.25
p.Y646C	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	DLNKYSPPP	CBL_PTK	642:650	Mutation altering degron motif	0.7087
p.Y646C	ACH-002263	Esophageal Cancer	CCLE	DLNKYSPPP	CBL_PTK	642:650	Mutation altering degron motif	0.7087
p.Y646C	KYSE-220	oesophagus	COSMIC	DLNKYSPPP	CBL_PTK	642:650	Mutation altering degron motif	0.7087
p.D11G	SIDM00820	Kidney Carcinoma	GDSC	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation altering degron motif	0.7198
p.D11G	ACH-002188	Kidney Cancer	CCLE	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation altering degron motif	0.7198
p.D11G	RCC-ER	kidney	COSMIC	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation altering degron motif	0.7198
p.A658T	SIDM00118	Colorectal Carcinoma	GDSC	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.1111
p.A658T	ACH-001081	Colon/Colorectal Cancer	CCLE	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.1111
p.A658T	HCC2998	large intestine	COSMIC	DLNKYSPPP	CBL_PTK	642:650	Mutation rewiring degron network	0.1111
p.E20K	SIDM01504	Small Cell Lung Carcinoma	GDSC	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.25
p.E20K	ACH-000594	Lung Cancer	CCLE	DSGWELS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NAA35

UniProt ID: Q5VZE5

Entrez ID: 60560

Protein name: N-alpha-acetyltransferase 35, NatC auxiliary subunit (Embryonic growth-associated protein homolog) (Protein MAK10 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NAA35 in