DegronMD

Uniprot ID: Q5VZE5

Source protein: N-alpha-acetyltransferase 35, NatC auxiliary subunit

Source gene: NAA35

Class: DEG_SCF_TRCP1_1

Location: 11:17

E3 ligase: BTRC

DEGRON score: 0.9957

ASA_SCORE: 86.9143

COIL: 0.8794

CONS_SCORE: 0.2166

DSS_SCORE: 0.5555

HELIX: 0.0889

FCONS_SCORE: 1.0181

RIG_SCORE: 0.7296

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D11G	SIDM00820	Kidney Carcinoma	GDSC	DSGWELS	DEG_SCF_TRCP1_1	0.7198
p.D11G	ACH-002188	Kidney Cancer	CCLE	DSGWELS	DEG_SCF_TRCP1_1	0.7198
p.D11G	RCC-ER	kidney	COSMIC	DSGWELS	DEG_SCF_TRCP1_1	0.7198
p.K21T	TCGA-EO-A22R	UCEC	TCGA	DSGWELS	DEG_SCF_TRCP1_1	0.6667
p.K21T	DO42713	UCEC	ICGC	DSGWELS	DEG_SCF_TRCP1_1	0.6667
p.W14L	DO229019	LICA	ICGC	DSGWELS	DEG_SCF_TRCP1_1	0.5904
p.M18V	TCGA-50-5044	LUAD	TCGA	DSGWELS	DEG_SCF_TRCP1_1	0.3056
p.M18V	DO25584	LUAD	ICGC	DSGWELS	DEG_SCF_TRCP1_1	0.3056
p.D10Y	DO229050	LICA	ICGC	DSGWELS	DEG_SCF_TRCP1_1	0.3056
p.E20D	TCGA-D1-A16X	UCEC	TCGA	DSGWELS	DEG_SCF_TRCP1_1	0.25
p.E20D	DO41799	UCEC	ICGC	DSGWELS	DEG_SCF_TRCP1_1	0.25
p.D8H	DO223012	ESCA	ICGC	DSGWELS	DEG_SCF_TRCP1_1	0.25
p.K4N	DO50804	LIRI	ICGC	DSGWELS	DEG_SCF_TRCP1_1	0.25
p.E20K	SIDM01504	Small Cell Lung Carcinoma	GDSC	DSGWELS	DEG_SCF_TRCP1_1	0.25
p.E20K	ACH-000594	Lung Cancer	CCLE	DSGWELS	DEG_SCF_TRCP1_1	0.25
p.E23Q	TCGA-CR-6484	HNSC	TCGA	DSGWELS	DEG_SCF_TRCP1_1	0.1667
p.E23Q	DO15206	HNSC	ICGC	DSGWELS	DEG_SCF_TRCP1_1	0.1667
p.N26D	DO45049	LINC	ICGC	DSGWELS	DEG_SCF_TRCP1_1	0.0833

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZE5	N-alpha-acetyltransferase 35, NatC auxiliary subunit	DEG_SCF_TRCP1_1	11:17	DSGWELS	BTRC	0.9957	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons