DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DLQRYSNGP
Uniprot ID:
Q9P2Y4
Source protein:
Zinc finger protein 219
Source gene:
ZNF219
Class:
CBL_PTK
Location:
25:33
E3 ligase:
CBL
DEGRON score:
0.9908
ASA_SCORE:
67.2222
COIL:
0.6887
CONS_SCORE:
0.7856
DSS_SCORE:
0.503
HELIX:
0.142
FCONS_SCORE:
1.1164
RIG_SCORE:
0.7122
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P33S
DO224768
BRCA
ICGC
DLQRYSNGP
CBL_PTK
0.6752
p.S39L
DO222884
COCA
ICGC
DLQRYSNGP
CBL_PTK
0.1667
p.M42I
DO233804
GACA
ICGC
DLQRYSNGP
CBL_PTK
0.0833
p.P33L
SIDM01299
Colorectal Carcinoma
GDSC
DLQRYSNGP
CBL_PTK
0.7582
p.L40F
SIDM00333
Endometrial Carcinoma
GDSC
DLQRYSNGP
CBL_PTK
0.1389
p.L40F
ACH-000988
Endometrial/Uterine Cancer
CCLE
DLQRYSNGP
CBL_PTK
0.1389
p.L40F
MFE-319
endometrium
COSMIC
DLQRYSNGP
CBL_PTK
0.1389
p.V35M
SIDM00537
Colorectal Carcinoma
GDSC
DLQRYSNGP
CBL_PTK
0.2778
p.V35M
ACH-000982
Colon/Colorectal Cancer
CCLE
DLQRYSNGP
CBL_PTK
0.2778
p.V35M
ACH-001345
Colon/Colorectal Cancer
CCLE
DLQRYSNGP
CBL_PTK
0.2778
p.V35M
GP5d
large_intestine
COSMIC
DLQRYSNGP
CBL_PTK
0.2778
Drug responses associated with ZNF219 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DLQRYSNGP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P2Y4
Zinc finger protein 219
CBL_PTK
25:33
DLQRYSNGP
CBL
0.9908
More...
