DegronMD - Q9P2Y4(ZNF219)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R164C	TCGA-C5-A1MN	CESC	TCGA	APSSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.25
p.R164C	DO6257	CESC	ICGC	APSSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.25
p.S16L	TCGA-DD-AAE1	LIHC	TCGA	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation altering degron motif	0.7667
p.S16L	DO52254	LIHC	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation altering degron motif	0.7667
p.P9T	TCGA-EE-A29X	SKCM	TCGA	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation rewiring degron network	0.2222
p.P9T	DO37595	SKCM	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation rewiring degron network	0.2222
p.A157D	TCGA-EO-A22U	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7793
p.A157D	DO43755	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7793
p.A157D	SIDM00299	Other Sarcomas	GDSC	APSSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7793
p.A157D	ACH-002271	Sarcoma	CCLE	APSSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7793
p.A157D	MFH-ino	soft tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7793
p.E150Q	TCGA-JW-A5VL	CESC	TCGA	APSSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.1389
p.E150Q	DO49976	CESC	ICGC	APSSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.1389
p.A148V	TCGA-VQ-A94O	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.0833
p.A148V	DO222369	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.0833
p.P33S	DO224768	BRCA	ICGC	DLQRYSNGP	CBL_PTK	25:33	Mutation altering degron motif	0.6752
p.S39L	DO222884	COCA	ICGC	DLQRYSNGP	CBL_PTK	25:33	Mutation rewiring degron network	0.1667
p.P155S	DO229010	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.2778
p.G22D	DO234150	ESAD	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation altering degron motif	0.6087
p.A14T	DO234199	ESAD	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation altering degron motif	0.7139
p.A19S	DO234310	ESAD	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation altering degron motif	0.6477
p.M42I	DO233804	GACA	ICGC	DLQRYSNGP	CBL_PTK	25:33	Mutation rewiring degron network	0.0833
p.A14V	DO32893	PACA	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation altering degron motif	0.6936
p.E150D	DO229268	THCA	ICGC	APSSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.1389
p.P9L	DO229087	THCA	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation rewiring degron network	0.2222
p.C168R	DO43763	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.1389
p.P33L	SIDM01299	Colorectal Carcinoma	GDSC	DLQRYSNGP	CBL_PTK	25:33	Mutation altering degron motif	0.7582
p.L40F	SIDM00333	Endometrial Carcinoma	GDSC	DLQRYSNGP	CBL_PTK	25:33	Mutation rewiring degron network	0.1389
p.L40F	ACH-000988	Endometrial/Uterine Cancer	CCLE	DLQRYSNGP	CBL_PTK	25:33	Mutation rewiring degron network	0.1389
p.L40F	MFE-319	endometrium	COSMIC	DLQRYSNGP	CBL_PTK	25:33	Mutation rewiring degron network	0.1389
p.A8T	SIDM00596	Endometrial Carcinoma	GDSC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation rewiring degron network	0.1944
p.A8T	ACH-001517	Endometrial/Uterine Cancer	CCLE	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation rewiring degron network	0.1944
p.A8T	HEC-1	endometrium	COSMIC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation rewiring degron network	0.1944
p.E23K	SIDM01653	Non-Cancerous	GDSC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation altering degron motif	0.591
p.E23K	ACH-002351	Non-Cancerous	CCLE	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation altering degron motif	0.591
p.K171Q	SIDM01019	Acute Myeloid Leukemia	GDSC	APSSS	DEG_SPOP_SBC_1	157:161	Mutation substituting flanking lysine	0.1667
p.K171Q	ACH-002258	Leukemia	CCLE	APSSS	DEG_SPOP_SBC_1	157:161	Mutation substituting flanking lysine	0.1667
p.K171Q	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	157:161	Mutation substituting flanking lysine	0.1667
p.V35M	SIDM00537	Colorectal Carcinoma	GDSC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation rewiring degron network	0.0833
p.V35M	SIDM00537	Colorectal Carcinoma	GDSC	DLQRYSNGP	CBL_PTK	25:33	Mutation rewiring degron network	0.2778
p.V35M	ACH-000982	Colon/Colorectal Cancer	CCLE	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation rewiring degron network	0.0833
p.V35M	ACH-000982	Colon/Colorectal Cancer	CCLE	DLQRYSNGP	CBL_PTK	25:33	Mutation rewiring degron network	0.2778
p.V35M	ACH-001345	Colon/Colorectal Cancer	CCLE	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation rewiring degron network	0.0833
p.V35M	ACH-001345	Colon/Colorectal Cancer	CCLE	DLQRYSNGP	CBL_PTK	25:33	Mutation rewiring degron network	0.2778
p.V35M	GP5d	large intestine	COSMIC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation rewiring degron network	0.0833
p.V35M	GP5d	large intestine	COSMIC	DLQRYSNGP	CBL_PTK	25:33	Mutation rewiring degron network	0.2778
p.P6S	SIDM00537	Colorectal Carcinoma	GDSC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation blocking phosphorylation signal	0.5833
p.P6S	ACH-001345	Colon/Colorectal Cancer	CCLE	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation blocking phosphorylation signal	0.5833
p.P6S	GP5d	large intestine	COSMIC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	13:26	Mutation blocking phosphorylation signal	0.5833
p.S160L	ACH-000999	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7667

Kaplan plot for ZNF219 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF219

UniProt ID: Q9P2Y4

Entrez ID: 51222

Protein name: Zinc finger protein 219

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF219 in