DegronMD

Uniprot ID: Q9P2Y4

Source protein: Zinc finger protein 219

Source gene: ZNF219

Class: DEG_ODPH_VHL_1

Location: 13:26

E3 ligase: VHL

DEGRON score: 0.9982

ASA_SCORE: 63.15

COIL: 0.8264

CONS_SCORE: 0.7621

DSS_SCORE: 0.6247

HELIX: 0.0484

FCONS_SCORE: 1.0693

RIG_SCORE: 0.6595

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S16L	TCGA-DD-AAE1	LIHC	TCGA	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.7667
p.S16L	DO52254	LIHC	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.7667
p.A14T	DO234199	ESAD	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.7139
p.A14V	DO32893	PACA	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.6936
p.A19S	DO234310	ESAD	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.6477
p.G22D	DO234150	ESAD	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.6087
p.E23K	SIDM01653	Non-Cancerous	GDSC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.591
p.E23K	ACH-002351	Non-Cancerous	CCLE	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.591
p.P6S	SIDM00537	Colorectal Carcinoma	GDSC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.5833
p.P6S	ACH-001345	Colon/Colorectal Cancer	CCLE	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.5833
p.P6S	GP5d	large_intestine	COSMIC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.5833
p.P9T	TCGA-EE-A29X	SKCM	TCGA	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.2222
p.P9T	DO37595	SKCM	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.2222
p.P9L	DO229087	THCA	ICGC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.2222
p.A8T	SIDM00596	Endometrial Carcinoma	GDSC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.1944
p.A8T	ACH-001517	Endometrial/Uterine Cancer	CCLE	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.1944
p.A8T	HEC-1	endometrium	COSMIC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.1944
p.V35M	SIDM00537	Colorectal Carcinoma	GDSC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.0833
p.V35M	ACH-000982	Colon/Colorectal Cancer	CCLE	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.0833
p.V35M	ACH-001345	Colon/Colorectal Cancer	CCLE	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.0833
p.V35M	GP5d	large_intestine	COSMIC	LAPSPPAFDGELDL	DEG_ODPH_VHL_1	0.0833

Showing 1 to 21 of 21 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2Y4	Zinc finger protein 219	DEG_ODPH_VHL_1	13:26	LAPSPPAFDGELDL	VHL	0.9982	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons