DegronMD

Uniprot ID: P23497

Source protein: Nuclear autoantigen Sp-100

Source gene: SP100

Class: DEG_Kelch_Keap1_1

Location: 457:462

E3 ligase: KEAP1

DEGRON score: 0.8493

ASA_SCORE: 81.2333

COIL: 0.7013

CONS_SCORE: 0.3605

DSS_SCORE: 0.4718

HELIX: 0.2277

FCONS_SCORE: 0.8474

RIG_SCORE: 0.6241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F450L	TCGA-14-0866	GBM	TCGA	DLSNGE	DEG_Kelch_Keap1_1	0.1389
p.F450L	DO11878	GBM	ICGC	DLSNGE	DEG_Kelch_Keap1_1	0.1389
p.E466K	TCGA-A5-A0G2	UCEC	TCGA	DLSNGE	DEG_Kelch_Keap1_1	0.2222
p.E466K	DO41235	UCEC	ICGC	DLSNGE	DEG_Kelch_Keap1_1	0.2222
p.R449C	TCGA-A5-A0VP	UCEC	TCGA	DLSNGE	DEG_Kelch_Keap1_1	0.1111
p.R449C	SIDM00083	Glioblastoma	GDSC	DLSNGE	DEG_Kelch_Keap1_1	0.1111
p.R449C	SF539	central_nervous_system	COSMIC	DLSNGE	DEG_Kelch_Keap1_1	0.1111
p.S469R	TCGA-CR-5243	HNSC	TCGA	DLSNGE	DEG_Kelch_Keap1_1	0.1389
p.S469R	DO14494	HNSC	ICGC	DLSNGE	DEG_Kelch_Keap1_1	0.1389
p.S471F	TCGA-Z2-AA3V	SKCM	TCGA	DLSNGE	DEG_Kelch_Keap1_1	0.0833
p.S471F	DO51303	SKCM	ICGC	DLSNGE	DEG_Kelch_Keap1_1	0.0833
p.E463D	DO229038	LICA	ICGC	DLSNGE	DEG_Kelch_Keap1_1	0.3056
p.R467K	DO230971	LUSC	ICGC	DLSNGE	DEG_Kelch_Keap1_1	0.1944
p.R467K	DO224630	LUSC	ICGC	DLSNGE	DEG_Kelch_Keap1_1	0.1944
p.L464I	SIDM00084	Glioblastoma	GDSC	DLSNGE	DEG_Kelch_Keap1_1	0.2778
p.L464I	SIDM00524	Small Cell Lung Carcinoma	GDSC	DLSNGE	DEG_Kelch_Keap1_1	0.2778
p.S471Y	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	DLSNGE	DEG_Kelch_Keap1_1	0.0833
p.F450I	SIDM01768	Melanoma	GDSC	DLSNGE	DEG_Kelch_Keap1_1	0.1389
p.F450I	ACH-000899	Skin Cancer	CCLE	DLSNGE	DEG_Kelch_Keap1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23497	Nuclear autoantigen Sp-100	DEG_Kelch_Keap1_1	457:462	DLSNGE	KEAP1	0.8493	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons