DegronMD - P23497(SP100)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F450L	TCGA-14-0866	GBM	TCGA	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.1389
p.F450L	DO11878	GBM	ICGC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.1389
p.K536N	TCGA-17-Z022	LUAD	TCGA	LQRGR	SCF_FBXL2	546:550	Mutation substituting flanking lysine	0.1667
p.K536N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LQRGR	SCF_FBXL2	546:550	Mutation substituting flanking lysine	0.1667
p.K536N	ACH-002256	Leukemia	CCLE	LQRGR	SCF_FBXL2	546:550	Mutation substituting flanking lysine	0.1667
p.K536N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LQRGR	SCF_FBXL2	546:550	Mutation substituting flanking lysine	0.1667
p.R538S	TCGA-49-6743	LUAD	TCGA	LQRGR	SCF_FBXL2	546:550	Mutation rewiring degron network	0.1111
p.R538S	DO26092	LUAD	ICGC	LQRGR	SCF_FBXL2	546:550	Mutation rewiring degron network	0.1111
p.E466K	TCGA-A5-A0G2	UCEC	TCGA	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.2222
p.E466K	DO41235	UCEC	ICGC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.2222
p.R449C	TCGA-A5-A0VP	UCEC	TCGA	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.1111
p.R449C	SIDM00083	Glioblastoma	GDSC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.1111
p.R449C	SF539	central nervous system	COSMIC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.1111
p.S469R	TCGA-CR-5243	HNSC	TCGA	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.1389
p.S469R	DO14494	HNSC	ICGC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.1389
p.S471F	TCGA-Z2-AA3V	SKCM	TCGA	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.0833
p.S471F	DO51303	SKCM	ICGC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.0833
p.G545C	DO228976	LICA	ICGC	LQRGR	SCF_FBXL2	546:550	Mutation rewiring degron network	0.3056
p.G545C	DO229037	LICA	ICGC	LQRGR	SCF_FBXL2	546:550	Mutation rewiring degron network	0.3056
p.E463D	DO229038	LICA	ICGC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.3056
p.R467K	DO230971	LUSC	ICGC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.1944
p.R467K	DO224630	LUSC	ICGC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.1944
p.L464I	SIDM00084	Glioblastoma	GDSC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.2778
p.L464I	SIDM00524	Small Cell Lung Carcinoma	GDSC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.2778
p.R540I	SIDM00789	Colorectal Carcinoma	GDSC	LQRGR	SCF_FBXL2	546:550	Mutation rewiring degron network	0.1667
p.R540I	ACH-000997	Colon/Colorectal Cancer	CCLE	LQRGR	SCF_FBXL2	546:550	Mutation rewiring degron network	0.1667
p.R540I	HCT-15	large intestine	COSMIC	LQRGR	SCF_FBXL2	546:550	Mutation rewiring degron network	0.1667
p.S471Y	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.0833
p.F450I	SIDM01768	Melanoma	GDSC	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.1389
p.F450I	ACH-000899	Skin Cancer	CCLE	DLSNGE	DEG_Kelch_Keap1_1	457:462	Mutation rewiring degron network	0.1389

Kaplan plot for SP100 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SP100

UniProt ID: P23497

Entrez ID: 6672

Protein name: Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SP100 in