DegronMD

Uniprot ID: P23497

Source protein: Nuclear autoantigen Sp-100

Source gene: SP100

Class: SCF_FBXL2

Location: 546:550

E3 ligase: FBXL2

DEGRON score: 0.9907

ASA_SCORE: 135.46

COIL: 0.7732

CONS_SCORE: 0.4263

DSS_SCORE: 0.9066

HELIX: 0.1416

FCONS_SCORE: 1.0705

RIG_SCORE: 0.6197

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K536N	TCGA-17-Z022	LUAD	TCGA	LQRGR	SCF_FBXL2	0.1667
p.K536N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LQRGR	SCF_FBXL2	0.1667
p.K536N	ACH-002256	Leukemia	CCLE	LQRGR	SCF_FBXL2	0.1667
p.K536N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LQRGR	SCF_FBXL2	0.1667
p.R538S	TCGA-49-6743	LUAD	TCGA	LQRGR	SCF_FBXL2	0.1111
p.R538S	DO26092	LUAD	ICGC	LQRGR	SCF_FBXL2	0.1111
p.G545C	DO228976	LICA	ICGC	LQRGR	SCF_FBXL2	0.3056
p.G545C	DO229037	LICA	ICGC	LQRGR	SCF_FBXL2	0.3056
p.R540I	SIDM00789	Colorectal Carcinoma	GDSC	LQRGR	SCF_FBXL2	0.1667
p.R540I	ACH-000997	Colon/Colorectal Cancer	CCLE	LQRGR	SCF_FBXL2	0.1667
p.R540I	HCT-15	large_intestine	COSMIC	LQRGR	SCF_FBXL2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23497	Nuclear autoantigen Sp-100	SCF_FBXL2	546:550	LQRGR	FBXL2	0.9907	More...
Q8NCW6	Polypeptide N-acetylgalactosaminyltransferase 11	SCF_FBXL2	480:484	LQRGR	FBXL2	0.6683	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons