DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LQRGR
Uniprot ID:
P23497
Source protein:
Nuclear autoantigen Sp-100
Source gene:
SP100
Class:
SCF_FBXL2
Location:
546:550
E3 ligase:
FBXL2
DEGRON score:
0.9907
ASA_SCORE:
135.46
COIL:
0.7732
CONS_SCORE:
0.4263
DSS_SCORE:
0.9066
HELIX:
0.1416
FCONS_SCORE:
1.0705
RIG_SCORE:
0.6197
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G545C
DO228976
LICA
ICGC
LQRGR
SCF_FBXL2
0.3056
p.G545C
DO229037
LICA
ICGC
LQRGR
SCF_FBXL2
0.3056
p.K536N
TCGA-17-Z022
LUAD
TCGA
LQRGR
SCF_FBXL2
0.1667
p.K536N
SIDM01007
T-Lymphoblastic Leukemia
GDSC
LQRGR
SCF_FBXL2
0.1667
p.K536N
ACH-002256
Leukemia
CCLE
LQRGR
SCF_FBXL2
0.1667
p.K536N
KARPAS-45
haematopoietic_and_lymphoid_tissue
COSMIC
LQRGR
SCF_FBXL2
0.1667
p.R540I
SIDM00789
Colorectal Carcinoma
GDSC
LQRGR
SCF_FBXL2
0.1667
p.R540I
ACH-000997
Colon/Colorectal Cancer
CCLE
LQRGR
SCF_FBXL2
0.1667
p.R540I
HCT-15
large_intestine
COSMIC
LQRGR
SCF_FBXL2
0.1667
p.R538S
TCGA-49-6743
LUAD
TCGA
LQRGR
SCF_FBXL2
0.1111
p.R538S
DO26092
LUAD
ICGC
LQRGR
SCF_FBXL2
0.1111
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Drug responses associated with SP100 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of LQRGR
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P23497
Nuclear autoantigen Sp-100
SCF_FBXL2
546:550
LQRGR
FBXL2
0.9907
More...
Q8NCW6
Polypeptide N-acetylgalactosaminyltransferase 11
SCF_FBXL2
480:484
LQRGR
FBXL2
0.6683
More...
Showing 1 to 2 of 2 entries
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