DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LQRGR
Uniprot ID:
Q8NCW6
Source protein:
Polypeptide N-acetylgalactosaminyltransferase 11
Source gene:
GALNT11
Class:
SCF_FBXL2
Location:
480:484
E3 ligase:
FBXL2
DEGRON score:
0.6683
ASA_SCORE:
62.56
COIL:
0.2262
CONS_SCORE:
0.5033
DSS_SCORE:
0.5313
HELIX:
0.0058
FCONS_SCORE:
1.053
RIG_SCORE:
0.7652
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R482L
TCGA-17-Z052
LUAD
TCGA
LQRGR
SCF_FBXL2
0.8428
p.K492R
TCGA-AA-3811
COAD
TCGA
LQRGR
SCF_FBXL2
0.2222
p.K492R
DO7962
COAD
ICGC
LQRGR
SCF_FBXL2
0.2222
p.G473V
DO228948
LICA
ICGC
LQRGR
SCF_FBXL2
0.1389
Drug responses associated with GALNT11 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQRGR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P23497
Nuclear autoantigen Sp-100
SCF_FBXL2
546:550
LQRGR
FBXL2
0.9907
More...
Q8NCW6
Polypeptide N-acetylgalactosaminyltransferase 11
SCF_FBXL2
480:484
LQRGR
FBXL2
0.6683
More...
