DegronMD

Uniprot ID: Q8NCW6

Source protein: Polypeptide N-acetylgalactosaminyltransferase 11

Source gene: GALNT11

Class: SCF_FBXL2

Location: 480:484

E3 ligase: FBXL2

DEGRON score: 0.6683

ASA_SCORE: 62.56

COIL: 0.2262

CONS_SCORE: 0.5033

DSS_SCORE: 0.5313

HELIX: 0.0058

FCONS_SCORE: 1.053

RIG_SCORE: 0.7652

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R482L	TCGA-17-Z052	LUAD	TCGA	LQRGR	SCF_FBXL2	0.8428
p.K492R	TCGA-AA-3811	COAD	TCGA	LQRGR	SCF_FBXL2	0.2222
p.K492R	DO7962	COAD	ICGC	LQRGR	SCF_FBXL2	0.2222
p.G473V	DO228948	LICA	ICGC	LQRGR	SCF_FBXL2	0.1389

Showing 1 to 4 of 4 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23497	Nuclear autoantigen Sp-100	SCF_FBXL2	546:550	LQRGR	FBXL2	0.9907	More...
Q8NCW6	Polypeptide N-acetylgalactosaminyltransferase 11	SCF_FBXL2	480:484	LQRGR	FBXL2	0.6683	More...

Showing 1 to 2 of 2 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons