DegronMD

Uniprot ID: Q8N140

Source protein: EP300-interacting inhibitor of differentiation 3

Source gene: EID3

Class: DEG_Kelch_Keap1_1

Location: 15:20

E3 ligase: KEAP1

DEGRON score: 0.8181

ASA_SCORE: 89.1

COIL: 0.897

CONS_SCORE: 0.3031

DSS_SCORE: 0.3914

HELIX: 0.0905

FCONS_SCORE: 0.9003

RIG_SCORE: 0.6453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L28P	TCGA-AP-A1DK	UCEC	TCGA	DLSSGE	DEG_Kelch_Keap1_1	0.1111
p.L28P	DO42033	UCEC	ICGC	DLSSGE	DEG_Kelch_Keap1_1	0.1111
p.D24Y	TCGA-AP-A1DV	UCEC	TCGA	DLSSGE	DEG_Kelch_Keap1_1	0.2222
p.D24Y	DO43186	UCEC	ICGC	DLSSGE	DEG_Kelch_Keap1_1	0.2222
p.C12Y	DO233103	GACA	ICGC	DLSSGE	DEG_Kelch_Keap1_1	0.25
p.A10T	DO233748	GACA	ICGC	DLSSGE	DEG_Kelch_Keap1_1	0.1944
p.D22N	DO229275	THCA	ICGC	DLSSGE	DEG_Kelch_Keap1_1	0.2778
p.S18F	SIDM00672	Hepatocellular Carcinoma	GDSC	DLSSGE	DEG_Kelch_Keap1_1	0.9093
p.A9P	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	DLSSGE	DEG_Kelch_Keap1_1	0.1667
p.A9P	NCI-H2030	lung	COSMIC	DLSSGE	DEG_Kelch_Keap1_1	0.1667
p.L27R	SIDM00930	Osteosarcoma	GDSC	DLSSGE	DEG_Kelch_Keap1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N140	EP300-interacting inhibitor of differentiation 3	DEG_Kelch_Keap1_1	15:20	DLSSGE	KEAP1	0.8181	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons