DegronMD

Uniprot ID: P46821

Source protein: Microtubule-associated protein 1B

Source gene: MAP1B

Class: DEG_COP1_1

Location: 520:528

E3 ligase: COP1

DEGRON score: 0.9942

ASA_SCORE: 88.6778

COIL: 0.9109

CONS_SCORE: 0.5532

DSS_SCORE: 0.4914

HELIX: 0.0479

FCONS_SCORE: 0.9033

RIG_SCORE: 0.723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D520N	TCGA-24-1842	OV	TCGA	DLTGQVPTP	DEG_COP1_1	0.6932
p.D520N	DO27972	OV	ICGC	DLTGQVPTP	DEG_COP1_1	0.6932
p.A516T	TCGA-AA-A010	COAD	TCGA	DLTGQVPTP	DEG_COP1_1	0.2222
p.P526H	TCGA-XF-A9SP	BLCA	TCGA	DLTGQVPTP	DEG_COP1_1	0.7694
p.P526H	DO223598	BLCA	ICGC	DLTGQVPTP	DEG_COP1_1	0.7694
p.L521R	DO233732	GACA	ICGC	DLTGQVPTP	DEG_COP1_1	0.7316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_COP1_1	520:528	DLTGQVPTP	COP1	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons