DegronMD

Uniprot ID: Q9Y5I4

Source protein: Protocadherin alpha-C2

Source gene: PCDHAC2

Class: CBL_PTK

Location: 369:375

E3 ligase: CBL

DEGRON score: 0.9823

ASA_SCORE: 64.6857

COIL: 0.6827

CONS_SCORE: 0.5054

DSS_SCORE: 0.3734

HELIX: 0.0059

FCONS_SCORE: 0.8172

RIG_SCORE: 0.809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D369N	TCGA-4R-AA8I	LIHC	TCGA	DLYSPVP	CBL_PTK	0.5821
p.D369N	TCGA-EB-A5UN	SKCM	TCGA	DLYSPVP	CBL_PTK	0.5821
p.D369N	DO49657	LIHC	ICGC	DLYSPVP	CBL_PTK	0.5821
p.D369N	DO47267	SKCM	ICGC	DLYSPVP	CBL_PTK	0.5821
p.D369Y	TCGA-56-8305	LUSC	TCGA	DLYSPVP	CBL_PTK	0.7325
p.D369Y	DO223725	LUSC	ICGC	DLYSPVP	CBL_PTK	0.7325
p.T368M	TCGA-AJ-A3OK	UCEC	TCGA	DLYSPVP	CBL_PTK	0.3056
p.T368M	DO220898	MELA	ICGC	DLYSPVP	CBL_PTK	0.3056
p.T368M	DO43602	UCEC	ICGC	DLYSPVP	CBL_PTK	0.3056
p.E376D	TCGA-D1-A16X	UCEC	TCGA	DLYSPVP	CBL_PTK	0.3056
p.E376D	DO41799	UCEC	ICGC	DLYSPVP	CBL_PTK	0.3056
p.V366M	TCGA-D1-A1NZ	UCEC	TCGA	DLYSPVP	CBL_PTK	0.25
p.V366M	DO41536	UCEC	ICGC	DLYSPVP	CBL_PTK	0.25
p.E376Q	TCGA-DG-A2KK	CESC	TCGA	DLYSPVP	CBL_PTK	0.3056
p.E376Q	DO51595	CESC	ICGC	DLYSPVP	CBL_PTK	0.3056
p.E364D	DO229018	LICA	ICGC	DLYSPVP	CBL_PTK	0.1944
p.A362S	DO229006	LICA	ICGC	DLYSPVP	CBL_PTK	0.1389
p.P375S	SIDM00082	Melanoma	GDSC	DLYSPVP	CBL_PTK	0.6752
p.P375S	ACH-001190	Skin Cancer	CCLE	DLYSPVP	CBL_PTK	0.6752
p.P375S	SK-MEL-2	skin	COSMIC	DLYSPVP	CBL_PTK	0.6752
p.P380S	SIDM01727	Chronic Myelogenous Leukemia	GDSC	DLYSPVP	CBL_PTK	0.1944
p.L370P	SIDM00780	Colorectal Carcinoma	GDSC	DLYSPVP	CBL_PTK	0.6471
p.L370P	ACH-000967	Colon/Colorectal Cancer	CCLE	DLYSPVP	CBL_PTK	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5I4	Protocadherin alpha-C2	CBL_PTK	369:375	DLYSPVP	CBL	0.9823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons