DegronMD - Q9Y5I4(PCDHAC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D369N	TCGA-4R-AA8I	LIHC	TCGA	DLYSPVP	CBL_PTK	369:375	Mutation altering degron motif	0.5821
p.D369N	TCGA-EB-A5UN	SKCM	TCGA	DLYSPVP	CBL_PTK	369:375	Mutation altering degron motif	0.5821
p.D369N	DO49657	LIHC	ICGC	DLYSPVP	CBL_PTK	369:375	Mutation altering degron motif	0.5821
p.D369N	DO47267	SKCM	ICGC	DLYSPVP	CBL_PTK	369:375	Mutation altering degron motif	0.5821
p.D369Y	TCGA-56-8305	LUSC	TCGA	DLYSPVP	CBL_PTK	369:375	Mutation altering degron motif	0.7325
p.D369Y	DO223725	LUSC	ICGC	DLYSPVP	CBL_PTK	369:375	Mutation altering degron motif	0.7325
p.T368M	TCGA-AJ-A3OK	UCEC	TCGA	DLYSPVP	CBL_PTK	369:375	Mutation rewiring degron network	0.3056
p.T368M	DO220898	MELA	ICGC	DLYSPVP	CBL_PTK	369:375	Mutation rewiring degron network	0.3056
p.T368M	DO43602	UCEC	ICGC	DLYSPVP	CBL_PTK	369:375	Mutation rewiring degron network	0.3056
p.R318Q	TCGA-B5-A3FA	UCEC	TCGA	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.2778
p.R318Q	DO52402	UCEC	ICGC	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.2778
p.G315W	TCGA-CR-7398	HNSC	TCGA	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation altering degron motif	0.7825
p.G315W	DO14782	HNSC	ICGC	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation altering degron motif	0.7825
p.E376D	TCGA-D1-A16X	UCEC	TCGA	DLYSPVP	CBL_PTK	369:375	Mutation rewiring degron network	0.3056
p.E376D	DO41799	UCEC	ICGC	DLYSPVP	CBL_PTK	369:375	Mutation rewiring degron network	0.3056
p.V366M	TCGA-D1-A1NZ	UCEC	TCGA	DLYSPVP	CBL_PTK	369:375	Mutation rewiring degron network	0.25
p.V366M	DO41536	UCEC	ICGC	DLYSPVP	CBL_PTK	369:375	Mutation rewiring degron network	0.25
p.E376Q	TCGA-DG-A2KK	CESC	TCGA	DLYSPVP	CBL_PTK	369:375	Mutation rewiring degron network	0.3056
p.E376Q	DO51595	CESC	ICGC	DLYSPVP	CBL_PTK	369:375	Mutation rewiring degron network	0.3056
p.E364D	DO229018	LICA	ICGC	DLYSPVP	CBL_PTK	369:375	Mutation rewiring degron network	0.1944
p.A362S	DO229006	LICA	ICGC	DLYSPVP	CBL_PTK	369:375	Mutation rewiring degron network	0.1389
p.G321A	DO51081	PRAD	ICGC	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.1944
p.E304K	DO229446	SKCA	ICGC	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.1389
p.S301W	SIDM00791	Chronic Myelogenous Leukemia	GDSC	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.0556
p.S301W	ACH-000551	Leukemia	CCLE	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.0556
p.S301W	K-562	haematopoietic and lymphoid tissue	COSMIC	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.0556
p.P375S	SIDM00082	Melanoma	GDSC	DLYSPVP	CBL_PTK	369:375	Mutation altering degron motif	0.6752
p.P375S	ACH-001190	Skin Cancer	CCLE	DLYSPVP	CBL_PTK	369:375	Mutation altering degron motif	0.6752
p.P375S	SK-MEL-2	skin	COSMIC	DLYSPVP	CBL_PTK	369:375	Mutation altering degron motif	0.6752
p.I310T	SIDM01177	B-Lymphoblastic Leukemia	GDSC	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.3056
p.I310T	ACH-002308	Leukemia	CCLE	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.3056
p.I310T	SUP-B8	haematopoietic and lymphoid tissue	COSMIC	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.3056
p.L323M	SIDM00260	Gastric Carcinoma	GDSC	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.1389
p.L323M	ACH-002161	Gastric Cancer	CCLE	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.1389
p.L323M	MKN28	stomach	COSMIC	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.1389
p.D302G	SIDM00217	Colorectal Carcinoma	GDSC	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.0833
p.D302G	ACH-000999	Colon/Colorectal Cancer	CCLE	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.0833
p.D302G	SNU-1040	large intestine	COSMIC	DASTGE	DEG_Kelch_Keap1_1	311:316	Mutation rewiring degron network	0.0833
p.P380S	SIDM01727	Chronic Myelogenous Leukemia	GDSC	DLYSPVP	CBL_PTK	369:375	Mutation rewiring degron network	0.1944
p.L370P	SIDM00780	Colorectal Carcinoma	GDSC	DLYSPVP	CBL_PTK	369:375	Mutation altering degron motif	0.6471
p.L370P	ACH-000967	Colon/Colorectal Cancer	CCLE	DLYSPVP	CBL_PTK	369:375	Mutation altering degron motif	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHAC2

UniProt ID: Q9Y5I4

Entrez ID: 56134

Protein name: Protocadherin alpha-C2 (PCDH-alpha-C2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHAC2 in