DegronMD

Uniprot ID: Q9Y5I4

Source protein: Protocadherin alpha-C2

Source gene: PCDHAC2

Class: DEG_Kelch_Keap1_1

Location: 311:316

E3 ligase: KEAP1

DEGRON score: 0.9597

ASA_SCORE: 59.4667

COIL: 0.844

CONS_SCORE: 0.6219

DSS_SCORE: 0.2845

HELIX: 0.0203

FCONS_SCORE: 1.2149

RIG_SCORE: 0.7705

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R318Q	TCGA-B5-A3FA	UCEC	TCGA	DASTGE	DEG_Kelch_Keap1_1	0.2778
p.R318Q	DO52402	UCEC	ICGC	DASTGE	DEG_Kelch_Keap1_1	0.2778
p.G315W	TCGA-CR-7398	HNSC	TCGA	DASTGE	DEG_Kelch_Keap1_1	0.7825
p.G315W	DO14782	HNSC	ICGC	DASTGE	DEG_Kelch_Keap1_1	0.7825
p.G321A	DO51081	PRAD	ICGC	DASTGE	DEG_Kelch_Keap1_1	0.1944
p.E304K	DO229446	SKCA	ICGC	DASTGE	DEG_Kelch_Keap1_1	0.1389
p.S301W	SIDM00791	Chronic Myelogenous Leukemia	GDSC	DASTGE	DEG_Kelch_Keap1_1	0.0556
p.S301W	ACH-000551	Leukemia	CCLE	DASTGE	DEG_Kelch_Keap1_1	0.0556
p.S301W	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	DASTGE	DEG_Kelch_Keap1_1	0.0556
p.I310T	SIDM01177	B-Lymphoblastic Leukemia	GDSC	DASTGE	DEG_Kelch_Keap1_1	0.3056
p.I310T	ACH-002308	Leukemia	CCLE	DASTGE	DEG_Kelch_Keap1_1	0.3056
p.I310T	SUP-B8	haematopoietic_and_lymphoid_tissue	COSMIC	DASTGE	DEG_Kelch_Keap1_1	0.3056
p.L323M	SIDM00260	Gastric Carcinoma	GDSC	DASTGE	DEG_Kelch_Keap1_1	0.1389
p.L323M	ACH-002161	Gastric Cancer	CCLE	DASTGE	DEG_Kelch_Keap1_1	0.1389
p.L323M	MKN28	stomach	COSMIC	DASTGE	DEG_Kelch_Keap1_1	0.1389
p.D302G	SIDM00217	Colorectal Carcinoma	GDSC	DASTGE	DEG_Kelch_Keap1_1	0.0833
p.D302G	ACH-000999	Colon/Colorectal Cancer	CCLE	DASTGE	DEG_Kelch_Keap1_1	0.0833
p.D302G	SNU-1040	large_intestine	COSMIC	DASTGE	DEG_Kelch_Keap1_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons