DegronMD

Uniprot ID: Q9ULB4

Source protein: Cadherin-9

Source gene: CDH9

Class: DEG_COP1_1

Location: 162:171

E3 ligase: COP1

DEGRON score: 0.7706

ASA_SCORE: 50.24

COIL: 0.3745

CONS_SCORE: 0.7327

DSS_SCORE: 0.3707

HELIX: 0.0137

FCONS_SCORE: 0.9018

RIG_SCORE: 0.7914

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A166S	TCGA-55-A490	LUAD	TCGA	DLYTASVPEM	DEG_COP1_1	0.6477
p.A166S	DO24596	LUAD	ICGC	DLYTASVPEM	DEG_COP1_1	0.6477
p.I152S	TCGA-66-2744	LUSC	TCGA	DLYTASVPEM	DEG_COP1_1	0.0556
p.I152S	DO27025	LUSC	ICGC	DLYTASVPEM	DEG_COP1_1	0.0556
p.V168I	TCGA-66-2777	LUSC	TCGA	DLYTASVPEM	DEG_COP1_1	0.7076
p.V168I	DO27516	LUSC	ICGC	DLYTASVPEM	DEG_COP1_1	0.7076
p.I152M	TCGA-97-7554	LUAD	TCGA	DLYTASVPEM	DEG_COP1_1	0.0556
p.I152M	DO23592	LUAD	ICGC	DLYTASVPEM	DEG_COP1_1	0.0556
p.I152M	SIDM00292	Small Cell Lung Carcinoma	GDSC	DLYTASVPEM	DEG_COP1_1	0.0556
p.I152M	ACH-002077	Lung Cancer	CCLE	DLYTASVPEM	DEG_COP1_1	0.0556
p.I152M	LU-165	lung	COSMIC	DLYTASVPEM	DEG_COP1_1	0.0556
p.S167T	TCGA-AF-3914	READ	TCGA	DLYTASVPEM	DEG_COP1_1	0.6005
p.S167T	DO36475	READ	ICGC	DLYTASVPEM	DEG_COP1_1	0.6005
p.V174I	TCGA-AP-A0LM	UCEC	TCGA	DLYTASVPEM	DEG_COP1_1	0.25
p.V174I	DO43306	UCEC	ICGC	DLYTASVPEM	DEG_COP1_1	0.25
p.S177Y	TCGA-CA-6718	COAD	TCGA	DLYTASVPEM	DEG_COP1_1	0.1667
p.S177Y	DO7801	COAD	ICGC	DLYTASVPEM	DEG_COP1_1	0.1667
p.E156K	TCGA-FS-A1ZB	SKCM	TCGA	DLYTASVPEM	DEG_COP1_1	0.1667
p.E156K	DO37886	SKCM	ICGC	DLYTASVPEM	DEG_COP1_1	0.1667
p.T165N	TCGA-L5-A4OQ	ESCA	TCGA	DLYTASVPEM	DEG_COP1_1	0.7055
p.G175D	TCGA-UF-A719	HNSC	TCGA	DLYTASVPEM	DEG_COP1_1	0.2222
p.G175D	DO52105	HNSC	ICGC	DLYTASVPEM	DEG_COP1_1	0.2222
p.L163V	TCGA-V5-AASX	ESCA	TCGA	DLYTASVPEM	DEG_COP1_1	0.5654
p.L163V	DO234357	ESAD	ICGC	DLYTASVPEM	DEG_COP1_1	0.5654
p.L163V	SIDM01274	Esophageal Carcinoma	GDSC	DLYTASVPEM	DEG_COP1_1	0.5654
p.L163V	SIDM00835	Colorectal Carcinoma	GDSC	DLYTASVPEM	DEG_COP1_1	0.5654
p.L163V	ACH-000489	Colon/Colorectal Cancer	CCLE	DLYTASVPEM	DEG_COP1_1	0.5654
p.L163V	SW1116	large_intestine	COSMIC	DLYTASVPEM	DEG_COP1_1	0.5654
p.S177F	TCGA-YG-AA3O	SKCM	TCGA	DLYTASVPEM	DEG_COP1_1	0.1667
p.S177F	DO51299	SKCM	ICGC	DLYTASVPEM	DEG_COP1_1	0.1667
p.P169S	TCGA-ZP-A9CZ	LIHC	TCGA	DLYTASVPEM	DEG_COP1_1	0.6752
p.P169S	DO52330	LIHC	ICGC	DLYTASVPEM	DEG_COP1_1	0.6752
p.L163I	DO233118	GACA	ICGC	DLYTASVPEM	DEG_COP1_1	0.6063
p.Q180E	DO233088	GACA	ICGC	DLYTASVPEM	DEG_COP1_1	0.0833
p.G173A	SIDM00189	Melanoma	GDSC	DLYTASVPEM	DEG_COP1_1	0.2778
p.G173A	ACH-002098	Skin Cancer	CCLE	DLYTASVPEM	DEG_COP1_1	0.2778
p.G173A	CP67-MEL	skin	COSMIC	DLYTASVPEM	DEG_COP1_1	0.2778
p.K158T	SIDM00193	Colorectal Carcinoma	GDSC	DLYTASVPEM	DEG_COP1_1	0.3333
p.K158T	ACH-000991	Colon/Colorectal Cancer	CCLE	DLYTASVPEM	DEG_COP1_1	0.3333
p.K158T	SNU-81	large_intestine	COSMIC	DLYTASVPEM	DEG_COP1_1	0.3333
p.S167I	SIDM00522	Small Cell Lung Carcinoma	GDSC	DLYTASVPEM	DEG_COP1_1	0.623
p.S167I	ACH-000749	Lung Cancer	CCLE	DLYTASVPEM	DEG_COP1_1	0.623
p.S167I	DMS-273	lung	COSMIC	DLYTASVPEM	DEG_COP1_1	0.623

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DLYTASVPEM

Degron related mutations and impact score

Drug responses associated with CDH9 mutations

All proteins holding degron of DLYTASVPEM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULB4	Cadherin-9	DEG_COP1_1	162:171	DLYTASVPEM	COP1	0.7706	More...