DegronMD - Q9ULB4(CDH9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D376V	TCGA-06-0173	GBM	TCGA	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.0556
p.D376V	DO10886	GBM	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.0556
p.A166S	TCGA-55-A490	LUAD	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6477
p.A166S	DO24596	LUAD	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6477
p.N351K	TCGA-5C-A9VG	LIHC	TCGA	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.0556
p.N351K	DO52163	LIHC	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.0556
p.N351T	TCGA-5C-A9VG	LIHC	TCGA	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.0556
p.N351T	DO52163	LIHC	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.0556
p.I152S	TCGA-66-2744	LUSC	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.0556
p.I152S	DO27025	LUSC	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.0556
p.V168I	TCGA-66-2777	LUSC	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.7076
p.V168I	DO27516	LUSC	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.7076
p.P354H	TCGA-66-2795	LUSC	TCGA	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.1389
p.P354H	DO23544	LIRI	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.1389
p.P354H	DO26710	LUSC	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.1389
p.V370F	TCGA-77-8136	LUSC	TCGA	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.2222
p.V370F	DO26593	LUSC	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.2222
p.L361M	TCGA-85-A512	LUSC	TCGA	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation altering degron motif	0.5999
p.L361M	DO45425	LUSC	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation altering degron motif	0.5999
p.L361M	DO222818	MELA	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation altering degron motif	0.5999
p.I152M	TCGA-97-7554	LUAD	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.0556
p.I152M	DO23592	LUAD	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.0556
p.I152M	SIDM00292	Small Cell Lung Carcinoma	GDSC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.0556
p.I152M	ACH-002077	Lung Cancer	CCLE	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.0556
p.I152M	LU-165	lung	COSMIC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.0556
p.T367I	TCGA-A5-A0G2	UCEC	TCGA	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.3056
p.T367I	DO41235	UCEC	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.3056
p.S167T	TCGA-AF-3914	READ	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6005
p.S167T	DO36475	READ	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6005
p.F364L	TCGA-AG-3892	READ	TCGA	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation altering degron motif	0.6981
p.F364L	DO36394	READ	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation altering degron motif	0.6981
p.V174I	TCGA-AP-A0LM	UCEC	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.25
p.V174I	DO43306	UCEC	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.25
p.P363R	TCGA-AY-4071	COAD	TCGA	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation altering degron motif	0.7512
p.P363R	DO9146	COAD	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation altering degron motif	0.7512
p.K365E	TCGA-BR-8680	STAD	TCGA	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation altering degron motif	0.591
p.K365E	DO47769	STAD	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation altering degron motif	0.591
p.S177Y	TCGA-CA-6718	COAD	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1667
p.S177Y	DO7801	COAD	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1667
p.E375K	TCGA-EB-A5UM	SKCM	TCGA	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.0833
p.E375K	DO47282	SKCM	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.0833
p.E375K	ACH-001607	Gallbladder Cancer	CCLE	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.0833
p.E156K	TCGA-FS-A1ZB	SKCM	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1667
p.E156K	DO37886	SKCM	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1667
p.T165N	TCGA-L5-A4OQ	ESCA	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.7055
p.G175D	TCGA-UF-A719	HNSC	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175D	DO52105	HNSC	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.L163V	TCGA-V5-AASX	ESCA	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.5654
p.L163V	DO234357	ESAD	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.5654
p.L163V	SIDM01274	Esophageal Carcinoma	GDSC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.5654
p.L163V	SIDM00835	Colorectal Carcinoma	GDSC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.5654
p.L163V	ACH-000489	Colon/Colorectal Cancer	CCLE	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.5654
p.L163V	SW1116	large intestine	COSMIC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.5654
p.S177F	TCGA-YG-AA3O	SKCM	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1667
p.S177F	DO51299	SKCM	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1667
p.P169S	TCGA-ZP-A9CZ	LIHC	TCGA	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6752
p.P169S	DO52330	LIHC	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6752
p.L359V	DO223377	CLLE	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.2778
p.P363L	DO6364	CLLE	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation altering degron motif	0.6471
p.I372L	DO50307	ESAD	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.1667
p.H353R	DO234446	ESAD	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.1111
p.L163I	DO233118	GACA	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6063
p.Q180E	DO233088	GACA	ICGC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.0833
p.T367K	DO228974	LICA	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.3056
p.P363T	DO48727	LIRI	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation altering degron motif	0.7031
p.R357Q	DO229494	SKCA	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.2222
p.R357Q	DO218863	SKCA	ICGC	LGPFKD	LIG_APCC_ABBA_1	361:366	Mutation rewiring degron network	0.2222
p.G173A	SIDM00189	Melanoma	GDSC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2778
p.G173A	ACH-002098	Skin Cancer	CCLE	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2778
p.G173A	CP67-MEL	skin	COSMIC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2778
p.K158T	SIDM00193	Colorectal Carcinoma	GDSC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation substituting flanking lysine	0.3333
p.K158T	ACH-000991	Colon/Colorectal Cancer	CCLE	DLYTASVPEM	DEG_COP1_1	162:171	Mutation substituting flanking lysine	0.3333
p.K158T	SNU-81	large intestine	COSMIC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation substituting flanking lysine	0.3333
p.S167I	SIDM00522	Small Cell Lung Carcinoma	GDSC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.623
p.S167I	ACH-000749	Lung Cancer	CCLE	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.623
p.S167I	DMS-273	lung	COSMIC	DLYTASVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.623

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH9

UniProt ID: Q9ULB4

Entrez ID: 1007

Protein name: Cadherin-9

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH9 in