DegronMD

Uniprot ID: Q9ULB4

Source protein: Cadherin-9

Source gene: CDH9

Class: LIG_APCC_ABBA_1

Location: 361:366

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5374

ASA_SCORE: 62

COIL: 0.774

CONS_SCORE: 0.6192

DSS_SCORE: 0.2198

HELIX: 0.0345

FCONS_SCORE: 0.9591

RIG_SCORE: 0.7687

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D376V	TCGA-06-0173	GBM	TCGA	LGPFKD	LIG_APCC_ABBA_1	0.0556
p.D376V	DO10886	GBM	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.0556
p.N351K	TCGA-5C-A9VG	LIHC	TCGA	LGPFKD	LIG_APCC_ABBA_1	0.0556
p.N351K	DO52163	LIHC	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.0556
p.N351T	TCGA-5C-A9VG	LIHC	TCGA	LGPFKD	LIG_APCC_ABBA_1	0.0556
p.N351T	DO52163	LIHC	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.0556
p.P354H	TCGA-66-2795	LUSC	TCGA	LGPFKD	LIG_APCC_ABBA_1	0.1389
p.P354H	DO23544	LIRI	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.1389
p.P354H	DO26710	LUSC	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.1389
p.V370F	TCGA-77-8136	LUSC	TCGA	LGPFKD	LIG_APCC_ABBA_1	0.2222
p.V370F	DO26593	LUSC	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.2222
p.L361M	TCGA-85-A512	LUSC	TCGA	LGPFKD	LIG_APCC_ABBA_1	0.5999
p.L361M	DO45425	LUSC	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.5999
p.L361M	DO222818	MELA	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.5999
p.T367I	TCGA-A5-A0G2	UCEC	TCGA	LGPFKD	LIG_APCC_ABBA_1	0.3056
p.T367I	DO41235	UCEC	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.3056
p.F364L	TCGA-AG-3892	READ	TCGA	LGPFKD	LIG_APCC_ABBA_1	0.6981
p.F364L	DO36394	READ	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.6981
p.P363R	TCGA-AY-4071	COAD	TCGA	LGPFKD	LIG_APCC_ABBA_1	0.7512
p.P363R	DO9146	COAD	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.7512
p.K365E	TCGA-BR-8680	STAD	TCGA	LGPFKD	LIG_APCC_ABBA_1	0.591
p.K365E	DO47769	STAD	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.591
p.E375K	TCGA-EB-A5UM	SKCM	TCGA	LGPFKD	LIG_APCC_ABBA_1	0.0833
p.E375K	DO47282	SKCM	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.0833
p.E375K	ACH-001607	Gallbladder Cancer	CCLE	LGPFKD	LIG_APCC_ABBA_1	0.0833
p.L359V	DO223377	CLLE	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.2778
p.P363L	DO6364	CLLE	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.6471
p.I372L	DO50307	ESAD	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.1667
p.H353R	DO234446	ESAD	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.1111
p.T367K	DO228974	LICA	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.3056
p.P363T	DO48727	LIRI	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.7031
p.R357Q	DO229494	SKCA	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.2222
p.R357Q	DO218863	SKCA	ICGC	LGPFKD	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGPFKD

Degron related mutations and impact score

Drug responses associated with CDH9 mutations

All proteins holding degron of LGPFKD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULB4	Cadherin-9	LIG_APCC_ABBA_1	361:366	LGPFKD	APC,CDC20,FZR1	0.5374	More...