DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DLYTFHP
Uniprot ID:
Q9Y242
Source protein:
Transcription factor 19
Source gene:
TCF19
Class:
CBL_PTK
Location:
17:23
E3 ligase:
CBL
DEGRON score:
0.7321
ASA_SCORE:
51.5429
COIL:
0.6251
CONS_SCORE:
0.8607
DSS_SCORE:
0.1865
HELIX:
0.1219
FCONS_SCORE:
1.1542
RIG_SCORE:
0.7777
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G11W
TCGA-A5-A1OF
UCEC
TCGA
DLYTFHP
CBL_PTK
0.1667
p.G11W
DO42568
UCEC
ICGC
DLYTFHP
CBL_PTK
0.1667
p.R9H
TCGA-BR-8360
STAD
TCGA
DLYTFHP
CBL_PTK
0.5556
p.R9H
DO47745
STAD
ICGC
DLYTFHP
CBL_PTK
0.5556
p.H22P
DO219881
SKCA
ICGC
DLYTFHP
CBL_PTK
0.6583
p.G26R
SIDM00794
Other Solid Cancers
GDSC
DLYTFHP
CBL_PTK
0.25
p.G13D
ACH-000979
Prostate Cancer
CCLE
DLYTFHP
CBL_PTK
0.2222
p.R32H
ACH-001377
Pancreatic Cancer
CCLE
DLYTFHP
CBL_PTK
0.0833
Drug responses associated with TCF19 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DLYTFHP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y242
Transcription factor 19
CBL_PTK
17:23
DLYTFHP
CBL
0.7321
More...
