DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DLYTPAP
Uniprot ID:
Q9NWS0
Source protein:
PIH1 domain-containing protein 1
Source gene:
PIH1D1
Class:
CBL_PTK
Location:
192:198
E3 ligase:
CBL
DEGRON score:
0.9802
ASA_SCORE:
70.6571
COIL:
0.7684
CONS_SCORE:
0.3586
DSS_SCORE:
0.6438
HELIX:
0.0804
FCONS_SCORE:
0.9145
RIG_SCORE:
0.6747
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A197T
TCGA-78-7539
LUAD
TCGA
DLYTPAP
CBL_PTK
0.6028
p.A197T
DO234239
ESAD
ICGC
DLYTPAP
CBL_PTK
0.6028
p.A197T
DO26210
LUAD
ICGC
DLYTPAP
CBL_PTK
0.6028
p.R186Q
DO229327
BTCA
ICGC
DLYTPAP
CBL_PTK
0.1667
p.P185S
DO234403
ESAD
ICGC
DLYTPAP
CBL_PTK
0.1389
p.P196T
DO228985
LICA
ICGC
DLYTPAP
CBL_PTK
0.5919
p.P196T
DO229008
LICA
ICGC
DLYTPAP
CBL_PTK
0.5919
p.P185L
DO228624
PRAD
ICGC
DLYTPAP
CBL_PTK
0.1389
p.S203A
SIDM01113
Other Sarcomas
GDSC
DLYTPAP
CBL_PTK
0.1944
p.S203A
ACH-000939
Sarcoma
CCLE
DLYTPAP
CBL_PTK
0.1944
p.S203A
SK-UT-1
soft_tissue
COSMIC
DLYTPAP
CBL_PTK
0.1944
p.L190P
SIDM00214
Colorectal Carcinoma
GDSC
DLYTPAP
CBL_PTK
0.2778
p.L190P
ACH-000955
Colon/Colorectal Cancer
CCLE
DLYTPAP
CBL_PTK
0.2778
p.L190P
SNU-407
large_intestine
COSMIC
DLYTPAP
CBL_PTK
0.2778
p.A197V
SIDM01451
Pancreatic Carcinoma
GDSC
DLYTPAP
CBL_PTK
0.5825
p.A197V
ACH-000933
Pancreatic Cancer
CCLE
DLYTPAP
CBL_PTK
0.5825
Drug responses associated with PIH1D1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DLYTPAP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NWS0
PIH1 domain-containing protein 1
CBL_PTK
192:198
DLYTPAP
CBL
0.9802
More...
