DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DNCYSNYP
Uniprot ID:
Q9NP62
Source protein:
Chorion-specific transcription factor GCMa
Source gene:
GCM1
Class:
CBL_PTK
Location:
310:317
E3 ligase:
CBL
DEGRON score:
0.9794
ASA_SCORE:
51.5375
COIL:
0.838
CONS_SCORE:
0.3514
DSS_SCORE:
0.1401
HELIX:
0.0769
FCONS_SCORE:
0.8923
RIG_SCORE:
0.7772
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N306T
TCGA-A5-A1OF
UCEC
TCGA
DNCYSNYP
CBL_PTK
0.2222
p.N306T
DO42568
UCEC
ICGC
DNCYSNYP
CBL_PTK
0.2222
p.F327L
TCGA-AA-A010
COAD
TCGA
DNCYSNYP
CBL_PTK
0.0556
p.S322N
TCGA-B7-5816
STAD
TCGA
DNCYSNYP
CBL_PTK
0.6389
p.S322N
DO38599
STAD
ICGC
DNCYSNYP
CBL_PTK
0.6389
p.A309S
TCGA-BS-A0UV
UCEC
TCGA
DNCYSNYP
CBL_PTK
0.3056
p.A309S
DO42793
UCEC
ICGC
DNCYSNYP
CBL_PTK
0.3056
p.N315S
TCGA-DK-A6B1
BLCA
TCGA
DNCYSNYP
CBL_PTK
0.5958
p.N315S
DO48534
BLCA
ICGC
DNCYSNYP
CBL_PTK
0.5958
p.R305K
DO48431
BLCA
ICGC
DNCYSNYP
CBL_PTK
0.1944
p.N300I
DO222363
MELA
ICGC
DNCYSNYP
CBL_PTK
0.0556
p.H307N
SIDM01619
Endometrial Carcinoma
GDSC
DNCYSNYP
CBL_PTK
0.25
p.H307N
ACH-000984
Endometrial/Uterine Cancer
CCLE
DNCYSNYP
CBL_PTK
0.25
Drug responses associated with GCM1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DNCYSNYP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NP62
Chorion-specific transcription factor GCMa
CBL_PTK
310:317
DNCYSNYP
CBL
0.9794
More...
