DegronMD - Q9NP62(GCM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R436K	TCGA-37-3783	LUSC	TCGA	PLR	DEG_APCC_TPR_1	434:436	Mutation altering degron motif	0.7237
p.R436K	DO26734	LUSC	ICGC	PLR	DEG_APCC_TPR_1	434:436	Mutation altering degron motif	0.7237
p.N431K	TCGA-77-A5G3	LUSC	TCGA	PLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.25
p.N431K	DO45456	LUSC	ICGC	PLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.25
p.N306T	TCGA-A5-A1OF	UCEC	TCGA	DNCYSNYP	CBL_PTK	310:317	Mutation rewiring degron network	0.2222
p.N306T	DO42568	UCEC	ICGC	DNCYSNYP	CBL_PTK	310:317	Mutation rewiring degron network	0.2222
p.F327L	TCGA-AA-A010	COAD	TCGA	DNCYSNYP	CBL_PTK	310:317	Mutation rewiring degron network	0.0556
p.S322N	TCGA-B7-5816	STAD	TCGA	DNCYSNYP	CBL_PTK	310:317	Mutation blocking phosphorylation signal	0.6389
p.S322N	DO38599	STAD	ICGC	DNCYSNYP	CBL_PTK	310:317	Mutation blocking phosphorylation signal	0.6389
p.A309S	TCGA-BS-A0UV	UCEC	TCGA	DNCYSNYP	CBL_PTK	310:317	Mutation rewiring degron network	0.3056
p.A309S	DO42793	UCEC	ICGC	DNCYSNYP	CBL_PTK	310:317	Mutation rewiring degron network	0.3056
p.C433Y	TCGA-CJ-4902	KIRC	TCGA	PLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.3056
p.C433Y	DO17693	KIRC	ICGC	PLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.3056
p.N315S	TCGA-DK-A6B1	BLCA	TCGA	DNCYSNYP	CBL_PTK	310:317	Mutation altering degron motif	0.5958
p.N315S	DO48534	BLCA	ICGC	DNCYSNYP	CBL_PTK	310:317	Mutation altering degron motif	0.5958
p.M428T	TCGA-LI-A67I	SARC	TCGA	PLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.1667
p.M428T	DO220201	SARC	ICGC	PLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.1667
p.R305K	DO48431	BLCA	ICGC	DNCYSNYP	CBL_PTK	310:317	Mutation rewiring degron network	0.1944
p.P434H	DO234199	ESAD	ICGC	PLR	DEG_APCC_TPR_1	434:436	Mutation altering degron motif	0.6583
p.N300I	DO222363	MELA	ICGC	DNCYSNYP	CBL_PTK	310:317	Mutation rewiring degron network	0.0556
p.H307N	SIDM01619	Endometrial Carcinoma	GDSC	DNCYSNYP	CBL_PTK	310:317	Mutation rewiring degron network	0.25
p.H307N	ACH-000984	Endometrial/Uterine Cancer	CCLE	DNCYSNYP	CBL_PTK	310:317	Mutation rewiring degron network	0.25

Kaplan plot for GCM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GCM1

UniProt ID: Q9NP62

Entrez ID: 8521

Protein name: Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GCM1 in