DegronMD

Uniprot ID: Q9NP62

Source protein: Chorion-specific transcription factor GCMa

Source gene: GCM1

Class: DEG_APCC_TPR_1

Location: 434:436

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8833

ASA_SCORE: 119.4

COIL: 0.9057

CONS_SCORE: 0.4078

DSS_SCORE: 0.6166

HELIX: 0.0383

FCONS_SCORE: 0.9889

RIG_SCORE: 0.8435

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R436K	TCGA-37-3783	LUSC	TCGA	PLR	DEG_APCC_TPR_1	0.7237
p.R436K	DO26734	LUSC	ICGC	PLR	DEG_APCC_TPR_1	0.7237
p.P434H	DO234199	ESAD	ICGC	PLR	DEG_APCC_TPR_1	0.6583
p.C433Y	TCGA-CJ-4902	KIRC	TCGA	PLR	DEG_APCC_TPR_1	0.3056
p.C433Y	DO17693	KIRC	ICGC	PLR	DEG_APCC_TPR_1	0.3056
p.N431K	TCGA-77-A5G3	LUSC	TCGA	PLR	DEG_APCC_TPR_1	0.25
p.N431K	DO45456	LUSC	ICGC	PLR	DEG_APCC_TPR_1	0.25
p.M428T	TCGA-LI-A67I	SARC	TCGA	PLR	DEG_APCC_TPR_1	0.1667
p.M428T	DO220201	SARC	ICGC	PLR	DEG_APCC_TPR_1	0.1667

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NP62	Chorion-specific transcription factor GCMa	DEG_APCC_TPR_1	434:436	PLR	APC,CDC20,FZR1	0.8833	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons