DegronMD

Uniprot ID: P50549

Source protein: ETS translocation variant 1

Source gene: ETV1

Class: DEG_COP1_1

Location: 65:74

E3 ligase: COP1

DEGRON score: 0.9937

ASA_SCORE: 71.44

COIL: 0.7184

CONS_SCORE: 0.5177

DSS_SCORE: 0.4898

HELIX: 0.1644

FCONS_SCORE: 1.0335

RIG_SCORE: 0.7752

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F81V	TCGA-AA-A00N	COAD	TCGA	DNDEQFVPDY	DEG_COP1_1	0.1389
p.E55Q	TCGA-GV-A3QI	BLCA	TCGA	DNDEQFVPDY	DEG_COP1_1	0.0556
p.E55Q	DO470	BLCA	ICGC	DNDEQFVPDY	DEG_COP1_1	0.0556
p.P70L	DO51951	BLCA	ICGC	DNDEQFVPDY	DEG_COP1_1	0.7582
p.N78K	DO217931	BRCA	ICGC	DNDEQFVPDY	DEG_COP1_1	0.2222
p.G56A	DO1755	BRCA	ICGC	DNDEQFVPDY	DEG_COP1_1	0.0833
p.K58N	DO48242	ESCA	ICGC	DNDEQFVPDY	DEG_COP1_1	0.1389
p.S83Y	DO228925	LICA	ICGC	DNDEQFVPDY	DEG_COP1_1	0.0833
p.S77Y	DO228974	LICA	ICGC	DNDEQFVPDY	DEG_COP1_1	0.25
p.F81L	SIDM00435	Acute Myeloid Leukemia	GDSC	DNDEQFVPDY	DEG_COP1_1	0.1389
p.F81L	ACH-000369	Leukemia	CCLE	DNDEQFVPDY	DEG_COP1_1	0.1389
p.F81L	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	DNDEQFVPDY	DEG_COP1_1	0.1389
p.L79M	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	DNDEQFVPDY	DEG_COP1_1	0.1944
p.L79M	NCI-H2126	lung	COSMIC	DNDEQFVPDY	DEG_COP1_1	0.1944
p.H82Y	ACH-002173	Lung Cancer	CCLE	DNDEQFVPDY	DEG_COP1_1	0.1111
p.A84T	SNU-1040	large_intestine	COSMIC	DNDEQFVPDY	DEG_COP1_1	0.0556
p.A84S	SBC-5	lung	COSMIC	DNDEQFVPDY	DEG_COP1_1	0.0556
p.F63L	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	DNDEQFVPDY	DEG_COP1_1	0.2778
p.A62S	SBC-5	lung	COSMIC	DNDEQFVPDY	DEG_COP1_1	0.25
p.Q66E	BHY	upper_aerodigestive_tract	COSMIC	DNDEQFVPDY	DEG_COP1_1	0.6744
p.P80S	KM12	large_intestine	COSMIC	DNDEQFVPDY	DEG_COP1_1	0.1667
p.G73R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DNDEQFVPDY	DEG_COP1_1	0.7568
p.P80A	C-33-A	cervix	COSMIC	DNDEQFVPDY	DEG_COP1_1	0.1667
p.A62T	SNU-1040	large_intestine	COSMIC	DNDEQFVPDY	DEG_COP1_1	0.25
p.R75S	NCI-H1993	lung	COSMIC	DNDEQFVPDY	DEG_COP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons