DegronMD - P50549(ETV1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F81V	TCGA-AA-A00N	COAD	TCGA	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.1389
p.T143M	TCGA-AX-A1C9	UCEC	TCGA	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.8534
p.S146F	TCGA-CZ-5462	KIRC	TCGA	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation blocking phosphorylation signal	0.6944
p.E55Q	TCGA-GV-A3QI	BLCA	TCGA	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.0556
p.E55Q	DO470	BLCA	ICGC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.0556
p.P128L	TCGA-YF-AA3L	BLCA	TCGA	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.0833
p.P70L	DO51951	BLCA	ICGC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation altering degron motif	0.7582
p.R130C	DO219068	BLCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1389
p.E134Q	DO471	BLCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.25
p.N78K	DO217931	BRCA	ICGC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.2222
p.G56A	DO1755	BRCA	ICGC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.0833
p.R129C	DO1285	BRCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1111
p.R129C	DO9002	COAD	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1111
p.R129C	DO47769	STAD	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1111
p.R129C	DO41020	UCEC	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1111
p.R129C	DO41584	UCEC	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1111
p.R129C	DO42600	UCEC	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1111
p.R129H	DO9002	COAD	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1111
p.R150H	DO10140	COAD	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1389
p.R150H	DO8264	COAD	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1389
p.R150H	DO14162	HNSC	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1389
p.R150C	DO230326	COCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1389
p.R129S	DO222884	COCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1111
p.R129S	DO233210	GACA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1111
p.S138C	DO48284	ESCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.7541
p.K58N	DO48242	ESCA	ICGC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.1389
p.S138F	DO14160	HNSC	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.7982
p.G149V	DO18938	KIRC	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1667
p.S83Y	DO228925	LICA	ICGC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.0833
p.P146T	DO228948	LICA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation blocking phosphorylation signal	0.6944
p.S77Y	DO228974	LICA	ICGC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.25
p.P135T	DO228985	LICA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2778
p.P135T	DO229041	LICA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2778
p.P143T	DO229006	LICA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.7031
p.P151L	DO222837	MELA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1111
p.R150L	DO220279	SARC	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1389
p.R147M	DO229446	SKCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2222
p.E134K	DO37583	SKCM	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.25
p.P151S	DO50284	SKCM	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1111
p.P141S	DO47303	SKCM	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.6752
p.P141S	DO38051	SKCM	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.6752
p.T144M	DO41361	UCEC	ICGC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.3056
p.F81L	SIDM00435	Acute Myeloid Leukemia	GDSC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.1389
p.F81L	ACH-000369	Leukemia	CCLE	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.1389
p.F81L	MOLM-16	haematopoietic and lymphoid tissue	COSMIC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.1389
p.G131R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1667
p.G131R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1667
p.G131R	ACH-000995	Leukemia	CCLE	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1667
p.G131R	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1667
p.P147S	SIDM00889	Cervical Carcinoma	GDSC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2222
p.P147S	ACH-001333	Cervical Cancer	CCLE	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2222
p.P147S	C-33-A	cervix	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2222
p.P138A	SIDM00889	Cervical Carcinoma	GDSC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.6392
p.P138A	ACH-001333	Cervical Cancer	CCLE	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.6392
p.P138A	C-33-A	cervix	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.6392
p.L79M	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.1944
p.L79M	NCI-H2126	lung	COSMIC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.1944
p.R133S	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2222
p.R133S	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2222
p.R133S	ACH-000590	Lung Cancer	CCLE	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2222
p.R133S	ACH-001137	Lung Cancer	CCLE	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2222
p.R133S	NCI-H1993	lung	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2222
p.P138S	SIDM00150	Colorectal Carcinoma	GDSC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.5641
p.P138S	ACH-000969	Colon/Colorectal Cancer	CCLE	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.5641
p.P138S	KM12	large intestine	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.5641
p.P153A	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.0556
p.P153A	ACH-000942	Leukemia	CCLE	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.0556
p.V145L	ACH-000215	Brain Cancer	CCLE	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2778
p.H82Y	ACH-002173	Lung Cancer	CCLE	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.1111
p.G145R	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2778
p.A84T	SNU-1040	large intestine	COSMIC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.0556
p.P152A	C-33-A	cervix	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.0833
p.G149E	LNCaP-Clone-FGC	prostate	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1667
p.A84S	SBC-5	lung	COSMIC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.0556
p.P149L	DAN-G	pancreas	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1667
p.G140C	NCI-H650	lung	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.76
p.F63L	MOLM-16	haematopoietic and lymphoid tissue	COSMIC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.2778
p.A149T	HCT-15	large intestine	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1667
p.A62S	SBC-5	lung	COSMIC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.25
p.P129S	C-33-A	cervix	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1111
p.R147S	NCI-H1993	lung	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.2222
p.P136S	GP5d	large intestine	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.3056
p.Q66E	BHY	upper aerodigestive tract	COSMIC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation altering degron motif	0.6744
p.P80S	KM12	large intestine	COSMIC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.1667
p.P152S	KM12	large intestine	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.0833
p.G73R	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation altering degron motif	0.7568
p.T137A	PA-TU-8902	pancreas	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.7139
p.P80A	C-33-A	cervix	COSMIC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.1667
p.A127T	HCT-15	large intestine	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation substituting flanking lysine	0.1667
p.A62T	SNU-1040	large intestine	COSMIC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.25
p.S141N	HCT-15	large intestine	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation altering degron motif	0.5958
p.D130N	MCC13	skin	COSMIC	PPTPSST	DEG_SCF_FBW7_1	137:143	Mutation rewiring degron network	0.1389
p.R75S	NCI-H1993	lung	COSMIC	DNDEQFVPDY	DEG_COP1_1	65:74	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ETV1

UniProt ID: P50549

Entrez ID: 2115

Protein name: ETS translocation variant 1 (Ets-related protein 81)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ETV1 in