DegronMD

Uniprot ID: P50549

Source protein: ETS translocation variant 1

Source gene: ETV1

Class: DEG_SCF_FBW7_1

Location: 137:143

E3 ligase: FBXW7

DEGRON score: 0.6423

ASA_SCORE: 82.4143

COIL: 0.9547

CONS_SCORE: 0.4417

DSS_SCORE: 0.7392

HELIX: 0.0194

FCONS_SCORE: 0.9205

RIG_SCORE: 0.4915

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T143M	TCGA-AX-A1C9	UCEC	TCGA	PPTPSST	DEG_SCF_FBW7_1	0.8534
p.S146F	TCGA-CZ-5462	KIRC	TCGA	PPTPSST	DEG_SCF_FBW7_1	0.6944
p.P128L	TCGA-YF-AA3L	BLCA	TCGA	PPTPSST	DEG_SCF_FBW7_1	0.0833
p.R130C	DO219068	BLCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1389
p.E134Q	DO471	BLCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.25
p.R129C	DO1285	BRCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1111
p.R129C	DO9002	COAD	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1111
p.R129C	DO47769	STAD	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1111
p.R129C	DO41020	UCEC	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1111
p.R129C	DO41584	UCEC	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1111
p.R129C	DO42600	UCEC	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1111
p.R129H	DO9002	COAD	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1111
p.R150H	DO10140	COAD	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1389
p.R150H	DO8264	COAD	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1389
p.R150H	DO14162	HNSC	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1389
p.R150C	DO230326	COCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1389
p.R129S	DO222884	COCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1111
p.R129S	DO233210	GACA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1111
p.S138C	DO48284	ESCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.7541
p.S138F	DO14160	HNSC	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.7982
p.G149V	DO18938	KIRC	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1667
p.P146T	DO228948	LICA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.6944
p.P135T	DO228985	LICA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.2778
p.P135T	DO229041	LICA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.2778
p.P143T	DO229006	LICA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.7031
p.P151L	DO222837	MELA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1111
p.R150L	DO220279	SARC	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1389
p.R147M	DO229446	SKCA	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.2222
p.E134K	DO37583	SKCM	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.25
p.P151S	DO50284	SKCM	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.1111
p.P141S	DO47303	SKCM	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.6752
p.P141S	DO38051	SKCM	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.6752
p.T144M	DO41361	UCEC	ICGC	PPTPSST	DEG_SCF_FBW7_1	0.3056
p.G131R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPTPSST	DEG_SCF_FBW7_1	0.1667
p.G131R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPTPSST	DEG_SCF_FBW7_1	0.1667
p.G131R	ACH-000995	Leukemia	CCLE	PPTPSST	DEG_SCF_FBW7_1	0.1667
p.G131R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.1667
p.P147S	SIDM00889	Cervical Carcinoma	GDSC	PPTPSST	DEG_SCF_FBW7_1	0.2222
p.P147S	ACH-001333	Cervical Cancer	CCLE	PPTPSST	DEG_SCF_FBW7_1	0.2222
p.P147S	C-33-A	cervix	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.2222
p.P138A	SIDM00889	Cervical Carcinoma	GDSC	PPTPSST	DEG_SCF_FBW7_1	0.6392
p.P138A	ACH-001333	Cervical Cancer	CCLE	PPTPSST	DEG_SCF_FBW7_1	0.6392
p.P138A	C-33-A	cervix	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.6392
p.R133S	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PPTPSST	DEG_SCF_FBW7_1	0.2222
p.R133S	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	PPTPSST	DEG_SCF_FBW7_1	0.2222
p.R133S	ACH-000590	Lung Cancer	CCLE	PPTPSST	DEG_SCF_FBW7_1	0.2222
p.R133S	ACH-001137	Lung Cancer	CCLE	PPTPSST	DEG_SCF_FBW7_1	0.2222
p.R133S	NCI-H1993	lung	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.2222
p.P138S	SIDM00150	Colorectal Carcinoma	GDSC	PPTPSST	DEG_SCF_FBW7_1	0.5641
p.P138S	ACH-000969	Colon/Colorectal Cancer	CCLE	PPTPSST	DEG_SCF_FBW7_1	0.5641
p.P138S	KM12	large_intestine	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.5641
p.P153A	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPTPSST	DEG_SCF_FBW7_1	0.0556
p.P153A	ACH-000942	Leukemia	CCLE	PPTPSST	DEG_SCF_FBW7_1	0.0556
p.V145L	ACH-000215	Brain Cancer	CCLE	PPTPSST	DEG_SCF_FBW7_1	0.2778
p.G145R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.2778
p.P152A	C-33-A	cervix	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.0833
p.G149E	LNCaP-Clone-FGC	prostate	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.1667
p.P149L	DAN-G	pancreas	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.1667
p.G140C	NCI-H650	lung	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.76
p.A149T	HCT-15	large_intestine	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.1667
p.P129S	C-33-A	cervix	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.1111
p.R147S	NCI-H1993	lung	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.2222
p.P136S	GP5d	large_intestine	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.3056
p.P152S	KM12	large_intestine	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.0833
p.T137A	PA-TU-8902	pancreas	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.7139
p.A127T	HCT-15	large_intestine	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.1667
p.S141N	HCT-15	large_intestine	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.5958
p.D130N	MCC13	skin	COSMIC	PPTPSST	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPSST

Degron related mutations and impact score

Drug responses associated with ETV1 mutations

All proteins holding degron of PPTPSST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P50549	ETS translocation variant 1	DEG_SCF_FBW7_1	137:143	PPTPSST	FBXW7	0.6423	More...