DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DNEYSQPP
Uniprot ID:
P06127
Source protein:
T-cell surface glycoprotein CD5
Source gene:
CD5
Class:
CBL_PTK
Location:
450:457
E3 ligase:
CBL
DEGRON score:
0.999
ASA_SCORE:
81.025
COIL:
0.8711
CONS_SCORE:
0.9652
DSS_SCORE:
0.6923
HELIX:
0.09
FCONS_SCORE:
1.1131
RIG_SCORE:
0.624
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V449M
TCGA-CA-6717
COAD
TCGA
DNEYSQPP
CBL_PTK
0.3056
p.V449M
TCGA-PG-A917
UCEC
TCGA
DNEYSQPP
CBL_PTK
0.3056
p.V449M
DO8264
COAD
ICGC
DNEYSQPP
CBL_PTK
0.3056
p.V449M
DO52424
UCEC
ICGC
DNEYSQPP
CBL_PTK
0.3056
p.E452K
TCGA-CV-7568
HNSC
TCGA
DNEYSQPP
CBL_PTK
0.591
p.E452K
DO14160
HNSC
ICGC
DNEYSQPP
CBL_PTK
0.591
p.N443S
TCGA-D3-A3ML
SKCM
TCGA
DNEYSQPP
CBL_PTK
0.1389
p.N443S
DO47413
SKCM
ICGC
DNEYSQPP
CBL_PTK
0.1389
p.P456H
TCGA-GV-A3QK
BLCA
TCGA
DNEYSQPP
CBL_PTK
0.6583
p.P456H
DO563
BLCA
ICGC
DNEYSQPP
CBL_PTK
0.6583
p.S447P
TCGA-IB-7651
PAAD
TCGA
DNEYSQPP
CBL_PTK
0.6944
p.S447P
DO46657
PAAD
ICGC
DNEYSQPP
CBL_PTK
0.6944
p.H461R
DO229010
COCA
ICGC
DNEYSQPP
CBL_PTK
0.2222
p.H461R
DO229013
COCA
ICGC
DNEYSQPP
CBL_PTK
0.2222
p.H461R
DO229016
COCA
ICGC
DNEYSQPP
CBL_PTK
0.2222
p.H461R
DO229003
COCA
ICGC
DNEYSQPP
CBL_PTK
0.2222
p.H461R
DO229005
COCA
ICGC
DNEYSQPP
CBL_PTK
0.2222
p.Y465F
DO45035
LINC
ICGC
DNEYSQPP
CBL_PTK
0.5556
p.L462M
SIDM00150
Colorectal Carcinoma
GDSC
DNEYSQPP
CBL_PTK
0.1944
p.L462M
ACH-000969
Colon/Colorectal Cancer
CCLE
DNEYSQPP
CBL_PTK
0.1944
p.L462M
KM12
large_intestine
COSMIC
DNEYSQPP
CBL_PTK
0.1944
Drug responses associated with CD5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DNEYSQPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P06127
T-cell surface glycoprotein CD5
CBL_PTK
450:457
DNEYSQPP
CBL
0.999
More...