DegronMD - P06127(CD5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P146T	TCGA-66-2734	LUSC	TCGA	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7031
p.P146T	DO26430	LUSC	ICGC	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7031
p.V449M	TCGA-CA-6717	COAD	TCGA	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.3056
p.V449M	TCGA-PG-A917	UCEC	TCGA	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.3056
p.V449M	DO8264	COAD	ICGC	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.3056
p.V449M	DO52424	UCEC	ICGC	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.3056
p.E452K	TCGA-CV-7568	HNSC	TCGA	DNEYSQPP	CBL_PTK	450:457	Mutation altering degron motif	0.591
p.E452K	DO14160	HNSC	ICGC	DNEYSQPP	CBL_PTK	450:457	Mutation altering degron motif	0.591
p.N443S	TCGA-D3-A3ML	SKCM	TCGA	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.1389
p.N443S	DO47413	SKCM	ICGC	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.1389
p.I106T	TCGA-EL-A3ZH	THCA	TCGA	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.2778
p.I106T	DO39034	THCA	ICGC	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.2778
p.I106T	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.2778
p.I106T	CHP-126	autonomic ganglia	COSMIC	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.2778
p.P456H	TCGA-GV-A3QK	BLCA	TCGA	DNEYSQPP	CBL_PTK	450:457	Mutation altering degron motif	0.6583
p.P456H	DO563	BLCA	ICGC	DNEYSQPP	CBL_PTK	450:457	Mutation altering degron motif	0.6583
p.S447P	TCGA-IB-7651	PAAD	TCGA	DNEYSQPP	CBL_PTK	450:457	Mutation blocking phosphorylation signal	0.6944
p.S447P	DO46657	PAAD	ICGC	DNEYSQPP	CBL_PTK	450:457	Mutation blocking phosphorylation signal	0.6944
p.T139R	TCGA-KO-8408	KICH	TCGA	PTTTPEPT	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1111
p.T139R	TCGA-KO-8408	KICH	TCGA	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1389
p.T139R	DO220562	KICH	ICGC	PTTTPEPT	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1111
p.T139R	DO220562	KICH	ICGC	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1389
p.H461R	DO229010	COCA	ICGC	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.2222
p.H461R	DO229013	COCA	ICGC	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.2222
p.H461R	DO229016	COCA	ICGC	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.2222
p.H461R	DO229003	COCA	ICGC	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.2222
p.H461R	DO229005	COCA	ICGC	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.2222
p.A155S	DO229029	LICA	ICGC	PTTTPEPT	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.3056
p.A155S	DO229029	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1944
p.S103I	DO229036	LICA	ICGC	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation altering degron motif	0.623
p.Y465F	DO45035	LINC	ICGC	DNEYSQPP	CBL_PTK	450:457	Mutation blocking phosphorylation signal	0.5556
p.P89S	SIDM01197	Colorectal Carcinoma	GDSC	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.1111
p.P89S	ACH-000722	Colon/Colorectal Cancer	CCLE	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.1111
p.P89S	SNU-C1	large intestine	COSMIC	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.1111
p.P146L	SIDM00206	Glioblastoma	GDSC	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7582
p.P146L	SIDM00100	Mesothelioma	GDSC	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7582
p.S104L	SIDM00920	Breast Carcinoma	GDSC	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation altering degron motif	0.7667
p.S104L	ACH-000783	Breast Cancer	CCLE	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation altering degron motif	0.7667
p.S104L	CAMA-1	breast	COSMIC	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation altering degron motif	0.7667
p.P156S	SIDM00920	Breast Carcinoma	GDSC	PTTTPEPT	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2778
p.P156S	SIDM00920	Breast Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1667
p.P156S	ACH-000783	Breast Cancer	CCLE	PTTTPEPT	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2778
p.P156S	ACH-000783	Breast Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1667
p.P156S	CAMA-1	breast	COSMIC	PTTTPEPT	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2778
p.P156S	CAMA-1	breast	COSMIC	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1667
p.G87V	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.0556
p.G87V	ACH-000852	Lung Cancer	CCLE	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.0556
p.G87V	NCI-H1435	lung	COSMIC	VTYTPQSS	DEG_SCF_FBW7_1	97:104	Mutation rewiring degron network	0.0556
p.L462M	SIDM00150	Colorectal Carcinoma	GDSC	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.1944
p.L462M	ACH-000969	Colon/Colorectal Cancer	CCLE	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.1944
p.L462M	KM12	large intestine	COSMIC	DNEYSQPP	CBL_PTK	450:457	Mutation rewiring degron network	0.1944
p.P146Q	ACH-000149	Neuroblastoma	CCLE	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7035
p.P146Q	SK-N-SH	autonomic ganglia	COSMIC	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7035
p.T138K	ACH-000553	Lung Cancer	CCLE	PTTTPEPT	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.0833
p.T138K	ACH-000553	Lung Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD5

UniProt ID: P06127

Entrez ID: 921

Protein name: T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD5 in