DegronMD

Uniprot ID: P06127

Source protein: T-cell surface glycoprotein CD5

Source gene: CD5

Class: DEG_SCF_FBW7_1

Location: 147:154

E3 ligase: FBXW7

DEGRON score: 0.9138

ASA_SCORE: 88.5375

COIL: 0.9351

CONS_SCORE: 0.9139

DSS_SCORE: 0.8466

HELIX: 0.015

FCONS_SCORE: 1.1492

RIG_SCORE: 0.6236

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A155S	DO229029	LICA	ICGC	PTTTPEPT	DEG_SCF_FBW7_1	0.3056
p.P156S	SIDM00920	Breast Carcinoma	GDSC	PTTTPEPT	DEG_SCF_FBW7_1	0.2778
p.P156S	ACH-000783	Breast Cancer	CCLE	PTTTPEPT	DEG_SCF_FBW7_1	0.2778
p.P156S	CAMA-1	breast	COSMIC	PTTTPEPT	DEG_SCF_FBW7_1	0.2778
p.T139R	TCGA-KO-8408	KICH	TCGA	PTTTPEPT	DEG_SCF_FBW7_1	0.1111
p.T139R	DO220562	KICH	ICGC	PTTTPEPT	DEG_SCF_FBW7_1	0.1111
p.T138K	ACH-000553	Lung Cancer	CCLE	PTTTPEPT	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06127	T-cell surface glycoprotein CD5	DEG_SCF_FBW7_1	147:154	PTTTPEPT	FBXW7	0.9138	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons