DegronMD

Uniprot ID: P06127

Source protein: T-cell surface glycoprotein CD5

Source gene: CD5

Class: DEG_SCF_FBW7_1

Location: 97:104

E3 ligase: FBXW7

DEGRON score: 0.8495

ASA_SCORE: 71.2625

COIL: 0.8284

CONS_SCORE: 0.4019

DSS_SCORE: 0.0403

HELIX: 0.0453

FCONS_SCORE: 0.6631

RIG_SCORE: 0.8638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I106T	TCGA-EL-A3ZH	THCA	TCGA	VTYTPQSS	DEG_SCF_FBW7_1	0.2778
p.I106T	DO39034	THCA	ICGC	VTYTPQSS	DEG_SCF_FBW7_1	0.2778
p.I106T	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	VTYTPQSS	DEG_SCF_FBW7_1	0.2778
p.I106T	CHP-126	autonomic_ganglia	COSMIC	VTYTPQSS	DEG_SCF_FBW7_1	0.2778
p.S103I	DO229036	LICA	ICGC	VTYTPQSS	DEG_SCF_FBW7_1	0.623
p.P89S	SIDM01197	Colorectal Carcinoma	GDSC	VTYTPQSS	DEG_SCF_FBW7_1	0.1111
p.P89S	ACH-000722	Colon/Colorectal Cancer	CCLE	VTYTPQSS	DEG_SCF_FBW7_1	0.1111
p.P89S	SNU-C1	large_intestine	COSMIC	VTYTPQSS	DEG_SCF_FBW7_1	0.1111
p.S104L	SIDM00920	Breast Carcinoma	GDSC	VTYTPQSS	DEG_SCF_FBW7_1	0.7667
p.S104L	ACH-000783	Breast Cancer	CCLE	VTYTPQSS	DEG_SCF_FBW7_1	0.7667
p.S104L	CAMA-1	breast	COSMIC	VTYTPQSS	DEG_SCF_FBW7_1	0.7667
p.G87V	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	VTYTPQSS	DEG_SCF_FBW7_1	0.0556
p.G87V	ACH-000852	Lung Cancer	CCLE	VTYTPQSS	DEG_SCF_FBW7_1	0.0556
p.G87V	NCI-H1435	lung	COSMIC	VTYTPQSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06127	T-cell surface glycoprotein CD5	DEG_SCF_FBW7_1	97:104	VTYTPQSS	FBXW7	0.8495	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons