DegronMD

Uniprot ID: O95503

Source protein: Chromobox protein homolog 6

Source gene: CBX6

Class: DEG_SCF_SKP2-CKS1_1

Location: 287:294

E3 ligase: SKP2,CSK1

DEGRON score: 0.9586

ASA_SCORE: 95.15

COIL: 0.9534

CONS_SCORE: 0.4189

DSS_SCORE: 0.8401

HELIX: 0.0366

FCONS_SCORE: 0.9105

RIG_SCORE: 0.5661

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P292L	SIDM01113	Other Sarcomas	GDSC	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P292L	ACH-000412	Colon/Colorectal Cancer	CCLE	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P292L	ACH-000939	Sarcoma	CCLE	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	0.7582
p.D289N	ACH-000971	Colon/Colorectal Cancer	CCLE	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	0.6932
p.P301A	DO50383	ESAD	ICGC	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	0.5833
p.S303F	SIDM02018	Colorectal Carcinoma	GDSC	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	0.5278
p.V300M	ACH-000678	Gastric Cancer	CCLE	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P300S	ACH-002309	Sarcoma	CCLE	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P302T	TCGA-A5-A0G1	UCEC	TCGA	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95503	Chromobox protein homolog 6	DEG_SCF_SKP2-CKS1_1	287:294	DPDDTPPK	SKP2,CSK1	0.9586	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons