DegronMD - O95503(CBX6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A270S	TCGA-85-8584	LUSC	TCGA	PSPTPQSS	DEG_SCF_FBW7_1	279:286	Mutation rewiring degron network	0.0833
p.P302T	TCGA-A5-A0G1	UCEC	TCGA	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.1111
p.R162H	TCGA-A6-6780	COAD	TCGA	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1389
p.R162H	TCGA-L5-A8NM	ESCA	TCGA	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1389
p.R162H	DO10244	COAD	ICGC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1389
p.G145R	TCGA-AA-3502	COAD	TCGA	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1944
p.G145R	DO7775	COAD	ICGC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1944
p.P148L	TCGA-AJ-A3OJ	UCEC	TCGA	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.2778
p.P148L	DO10880	GBM	ICGC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.2778
p.P148L	DO232761	PBCA	ICGC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.2778
p.P148L	DO42753	UCEC	ICGC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.2778
p.Q140R	TCGA-AP-A1DK	UCEC	TCGA	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.0556
p.Q140R	DO42033	UCEC	ICGC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.0556
p.T156M	TCGA-AX-A2HD	UCEC	TCGA	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation blocking phosphorylation signal	0.75
p.R162C	TCGA-AZ-6601	COAD	TCGA	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1389
p.R162C	DO8119	COAD	ICGC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1389
p.I159T	TCGA-BG-A222	UCEC	TCGA	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.2222
p.I159T	DO42977	UCEC	ICGC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.2222
p.P281L	TCGA-EL-A3N2	THCA	TCGA	PSPTPQSS	DEG_SCF_FBW7_1	279:286	Mutation altering degron motif	0.6471
p.P281L	DO39155	THCA	ICGC	PSPTPQSS	DEG_SCF_FBW7_1	279:286	Mutation altering degron motif	0.6471
p.P301A	DO50383	ESAD	ICGC	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation blocking phosphorylation signal	0.5833
p.R158H	DO233104	GACA	ICGC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.25
p.E280K	DO233259	GACA	ICGC	PSPTPQSS	DEG_SCF_FBW7_1	279:286	Mutation altering degron motif	0.7022
p.P148S	DO42023	UCEC	ICGC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.2778
p.R155L	DO43891	UCEC	ICGC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation altering degron motif	0.8428
p.P284T	DO42472	UCEC	ICGC	PSPTPQSS	DEG_SCF_FBW7_1	279:286	Mutation altering degron motif	0.7031
p.A270T	SIDM02059	Colorectal Carcinoma	GDSC	PSPTPQSS	DEG_SCF_FBW7_1	279:286	Mutation rewiring degron network	0.0833
p.S303F	SIDM02018	Colorectal Carcinoma	GDSC	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation blocking phosphorylation signal	0.5278
p.S154L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation altering degron motif	0.6556
p.S154L	DND-41	haematopoietic and lymphoid tissue	COSMIC	ISPFSE	LIG_APCC_ABBA_1	150:155	Mutation altering degron motif	0.6556
p.S276F	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PSPTPQSS	DEG_SCF_FBW7_1	279:286	Mutation rewiring degron network	0.25
p.S276F	ACH-000636	Leukemia	CCLE	PSPTPQSS	DEG_SCF_FBW7_1	279:286	Mutation rewiring degron network	0.25
p.P292L	SIDM01113	Other Sarcomas	GDSC	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.7582
p.P292L	ACH-000412	Colon/Colorectal Cancer	CCLE	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.7582
p.P292L	ACH-000939	Sarcoma	CCLE	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.7582
p.V300M	ACH-000678	Gastric Cancer	CCLE	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.1667
p.S275F	ACH-000968	Skin Cancer	CCLE	PSPTPQSS	DEG_SCF_FBW7_1	279:286	Mutation rewiring degron network	0.2222
p.S275F	ACH-000987	Skin Cancer	CCLE	PSPTPQSS	DEG_SCF_FBW7_1	279:286	Mutation rewiring degron network	0.2222
p.D289N	ACH-000971	Colon/Colorectal Cancer	CCLE	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.6932
p.P300S	ACH-002309	Sarcoma	CCLE	DPDDTPPK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.1667

Kaplan plot for CBX6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CBX6

UniProt ID: O95503

Entrez ID: 23466

Protein name: Chromobox protein homolog 6

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CBX6 in