DegronMD

Uniprot ID: O95503

Source protein: Chromobox protein homolog 6

Source gene: CBX6

Class: DEG_SCF_FBW7_1

Location: 279:286

E3 ligase: FBXW7

DEGRON score: 0.9973

ASA_SCORE: 94.7125

COIL: 0.9658

CONS_SCORE: 0.5243

DSS_SCORE: 0.8336

HELIX: 0.017

FCONS_SCORE: 1.2451

RIG_SCORE: 0.4746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A270S	TCGA-85-8584	LUSC	TCGA	PSPTPQSS	DEG_SCF_FBW7_1	0.0833
p.P281L	TCGA-EL-A3N2	THCA	TCGA	PSPTPQSS	DEG_SCF_FBW7_1	0.6471
p.P281L	DO39155	THCA	ICGC	PSPTPQSS	DEG_SCF_FBW7_1	0.6471
p.E280K	DO233259	GACA	ICGC	PSPTPQSS	DEG_SCF_FBW7_1	0.7022
p.P284T	DO42472	UCEC	ICGC	PSPTPQSS	DEG_SCF_FBW7_1	0.7031
p.A270T	SIDM02059	Colorectal Carcinoma	GDSC	PSPTPQSS	DEG_SCF_FBW7_1	0.0833
p.S276F	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PSPTPQSS	DEG_SCF_FBW7_1	0.25
p.S276F	ACH-000636	Leukemia	CCLE	PSPTPQSS	DEG_SCF_FBW7_1	0.25
p.S275F	ACH-000968	Skin Cancer	CCLE	PSPTPQSS	DEG_SCF_FBW7_1	0.2222
p.S275F	ACH-000987	Skin Cancer	CCLE	PSPTPQSS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95503	Chromobox protein homolog 6	DEG_SCF_FBW7_1	279:286	PSPTPQSS	FBXW7	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons