DegronMD

Uniprot ID: O95503

Source protein: Chromobox protein homolog 6

Source gene: CBX6

Class: LIG_APCC_ABBA_1

Location: 150:155

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9728

ASA_SCORE: 88.6167

COIL: 0.8843

CONS_SCORE: 0.5484

DSS_SCORE: 0.5321

HELIX: 0.0837

FCONS_SCORE: 1.112

RIG_SCORE: 0.6679

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R162H	TCGA-A6-6780	COAD	TCGA	ISPFSE	LIG_APCC_ABBA_1	0.1389
p.R162H	TCGA-L5-A8NM	ESCA	TCGA	ISPFSE	LIG_APCC_ABBA_1	0.1389
p.R162H	DO10244	COAD	ICGC	ISPFSE	LIG_APCC_ABBA_1	0.1389
p.G145R	TCGA-AA-3502	COAD	TCGA	ISPFSE	LIG_APCC_ABBA_1	0.1944
p.G145R	DO7775	COAD	ICGC	ISPFSE	LIG_APCC_ABBA_1	0.1944
p.P148L	TCGA-AJ-A3OJ	UCEC	TCGA	ISPFSE	LIG_APCC_ABBA_1	0.2778
p.P148L	DO10880	GBM	ICGC	ISPFSE	LIG_APCC_ABBA_1	0.2778
p.P148L	DO232761	PBCA	ICGC	ISPFSE	LIG_APCC_ABBA_1	0.2778
p.P148L	DO42753	UCEC	ICGC	ISPFSE	LIG_APCC_ABBA_1	0.2778
p.Q140R	TCGA-AP-A1DK	UCEC	TCGA	ISPFSE	LIG_APCC_ABBA_1	0.0556
p.Q140R	DO42033	UCEC	ICGC	ISPFSE	LIG_APCC_ABBA_1	0.0556
p.T156M	TCGA-AX-A2HD	UCEC	TCGA	ISPFSE	LIG_APCC_ABBA_1	0.75
p.R162C	TCGA-AZ-6601	COAD	TCGA	ISPFSE	LIG_APCC_ABBA_1	0.1389
p.R162C	DO8119	COAD	ICGC	ISPFSE	LIG_APCC_ABBA_1	0.1389
p.I159T	TCGA-BG-A222	UCEC	TCGA	ISPFSE	LIG_APCC_ABBA_1	0.2222
p.I159T	DO42977	UCEC	ICGC	ISPFSE	LIG_APCC_ABBA_1	0.2222
p.R158H	DO233104	GACA	ICGC	ISPFSE	LIG_APCC_ABBA_1	0.25
p.P148S	DO42023	UCEC	ICGC	ISPFSE	LIG_APCC_ABBA_1	0.2778
p.R155L	DO43891	UCEC	ICGC	ISPFSE	LIG_APCC_ABBA_1	0.8428
p.S154L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ISPFSE	LIG_APCC_ABBA_1	0.6556
p.S154L	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	ISPFSE	LIG_APCC_ABBA_1	0.6556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95503	Chromobox protein homolog 6	LIG_APCC_ABBA_1	150:155	ISPFSE	APC,CDC20,FZR1	0.9728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons