DegronMD

Uniprot ID: Q5VT52

Source protein: Regulation of nuclear pre-mRNA domain-containing protein 2

Source gene: RPRD2

Class: DEG_COP1_1

Location: 315:324

E3 ligase: COP1

DEGRON score: 0.8927

ASA_SCORE: 86.53

COIL: 0.921

CONS_SCORE: 0.4902

DSS_SCORE: 0.7896

HELIX: 0.0607

FCONS_SCORE: 0.8967

RIG_SCORE: 0.5569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P322S	TCGA-DU-6407	LGG	TCGA	DPEESPVPSP	DEG_COP1_1	0.6752
p.S323F	TCGA-FR-A7U9	SKCM	TCGA	DPEESPVPSP	DEG_COP1_1	0.7982
p.S323F	SIDM00007	Other Solid Cancers	GDSC	DPEESPVPSP	DEG_COP1_1	0.7982
p.S323F	ACH-001550	Skin Cancer	CCLE	DPEESPVPSP	DEG_COP1_1	0.7982
p.S323F	MCC13	skin	COSMIC	DPEESPVPSP	DEG_COP1_1	0.7982
p.P324S	TCGA-GN-A267	SKCM	TCGA	DPEESPVPSP	DEG_COP1_1	0.6752
p.E328K	DO51612	CESC	ICGC	DPEESPVPSP	DEG_COP1_1	0.2222
p.E328K	SW954	vulva	COSMIC	DPEESPVPSP	DEG_COP1_1	0.2222
p.E334K	DO222441	ESCA	ICGC	DPEESPVPSP	DEG_COP1_1	0.0556
p.Q313H	DO228948	LICA	ICGC	DPEESPVPSP	DEG_COP1_1	0.2778
p.E309D	DO229022	LICA	ICGC	DPEESPVPSP	DEG_COP1_1	0.1667
p.G317S	DO229043	LICA	ICGC	DPEESPVPSP	DEG_COP1_1	0.6993
p.S322L	DO228414	MALY	ICGC	DPEESPVPSP	DEG_COP1_1	0.7667
p.P305S	DO222420	MELA	ICGC	DPEESPVPSP	DEG_COP1_1	0.1667
p.P311L	DO37782	SKCM	ICGC	DPEESPVPSP	DEG_COP1_1	0.2222
p.P329L	SIDM00140	Melanoma	GDSC	DPEESPVPSP	DEG_COP1_1	0.1944
p.P329L	ACH-000968	Skin Cancer	CCLE	DPEESPVPSP	DEG_COP1_1	0.1944
p.P329L	COLO-792	skin	COSMIC	DPEESPVPSP	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_COP1_1	315:324	DPEESPVPSP	COP1	0.8927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons