DegronMD

Uniprot ID: Q92904

Source protein: Deleted in azoospermia-like

Source gene: DAZL

Class: DEG_SIAH_1

Location: 220:228

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9983

ASA_SCORE: 52.3111

COIL: 0.8303

CONS_SCORE: 0.3201

DSS_SCORE: 0.4239

HELIX: 0.033

FCONS_SCORE: 0.8438

RIG_SCORE: 0.7107

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G218W	TCGA-43-3920	LUSC	TCGA	DPGAEVVPN	DEG_SIAH_1	0.2778
p.P227S	TCGA-A5-A2K5	UCEC	TCGA	DPGAEVVPN	DEG_SIAH_1	0.6752
p.P227L	TCGA-AA-A010	COAD	TCGA	DPGAEVVPN	DEG_SIAH_1	0.7582
p.V224A	TCGA-CU-A3QU	BLCA	TCGA	DPGAEVVPN	DEG_SIAH_1	0.6936
p.E238K	TCGA-EE-A29P	SKCM	TCGA	DPGAEVVPN	DEG_SIAH_1	0.0556
p.E238K	TCGA-EE-A3AF	SKCM	TCGA	DPGAEVVPN	DEG_SIAH_1	0.0556
p.N228I	DO228295	BRCA	ICGC	DPGAEVVPN	DEG_SIAH_1	0.6169
p.P221T	DO229031	LICA	ICGC	DPGAEVVPN	DEG_SIAH_1	0.7031
p.P221Q	DO229031	LICA	ICGC	DPGAEVVPN	DEG_SIAH_1	0.7035
p.A211D	DO229008	LICA	ICGC	DPGAEVVPN	DEG_SIAH_1	0.0833
p.E218K	DO37916	SKCM	ICGC	DPGAEVVPN	DEG_SIAH_1	0.2778
p.E218K	DO37911	SKCM	ICGC	DPGAEVVPN	DEG_SIAH_1	0.2778
p.P238S	ACH-000218	Leukemia	CCLE	DPGAEVVPN	DEG_SIAH_1	0.0556
p.P238S	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	DPGAEVVPN	DEG_SIAH_1	0.0556
p.G222E	ACH-000395	Lung Cancer	CCLE	DPGAEVVPN	DEG_SIAH_1	0.6087
p.G222E	NCI-H520	lung	COSMIC	DPGAEVVPN	DEG_SIAH_1	0.6087
p.C230Y	ACH-000998	Colon/Colorectal Cancer	CCLE	DPGAEVVPN	DEG_SIAH_1	0.2778
p.C230Y	CW-2	large_intestine	COSMIC	DPGAEVVPN	DEG_SIAH_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92904	Deleted in azoospermia-like	DEG_SIAH_1	220:228	DPGAEVVPN	SIAH1,SIAH2,SIAH3	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons