DegronMD - Q92904(DAZL)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G218W	TCGA-43-3920	LUSC	TCGA	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation rewiring degron network	0.2778
p.P227S	TCGA-A5-A2K5	UCEC	TCGA	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation altering degron motif	0.6752
p.P227L	TCGA-AA-A010	COAD	TCGA	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation altering degron motif	0.7582
p.A2V	TCGA-AP-A1DK	UCEC	TCGA	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation blocking phosphorylation signal	0.6667
p.A2V	DO42033	UCEC	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation blocking phosphorylation signal	0.6667
p.A2V	DO41199	UCEC	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation blocking phosphorylation signal	0.6667
p.V224A	TCGA-CU-A3QU	BLCA	TCGA	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation altering degron motif	0.6936
p.E238K	TCGA-EE-A29P	SKCM	TCGA	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation rewiring degron network	0.0556
p.E238K	TCGA-EE-A3AF	SKCM	TCGA	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation rewiring degron network	0.0556
p.A4T	DO219084	BLCA	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.2778
p.N228I	DO228295	BRCA	ICGC	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation altering degron motif	0.6169
p.T12A	DO230334	COCA	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation altering degron motif	0.7139
p.T12A	DO229003	COCA	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation altering degron motif	0.7139
p.T12A	DO229005	COCA	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation altering degron motif	0.7139
p.T12A	DO234285	ESAD	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation altering degron motif	0.7139
p.S5L	DO233867	GACA	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.3056
p.S5L	SIDM00049	Colorectal Carcinoma	GDSC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.3056
p.S5L	SIDM00179	Melanoma	GDSC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.3056
p.S5L	SIDM00176	Chondrosarcoma	GDSC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.3056
p.Q11L	DO228856	LICA	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation altering degron motif	0.7765
p.P221T	DO229031	LICA	ICGC	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation altering degron motif	0.7031
p.P221Q	DO229031	LICA	ICGC	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation altering degron motif	0.7035
p.L14M	DO229036	LICA	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.2778
p.P19L	DO229052	LICA	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.1389
p.T3A	DO229057	LICA	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.25
p.A211D	DO229008	LICA	ICGC	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation rewiring degron network	0.0833
p.N10K	DO45161	LIRI	ICGC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation altering degron motif	0.5806
p.E218K	DO37916	SKCM	ICGC	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation rewiring degron network	0.2778
p.E218K	DO37911	SKCM	ICGC	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation rewiring degron network	0.2778
p.R13H	SIDM00530	Esophageal Carcinoma	GDSC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.3056
p.F17L	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.1944
p.R13C	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.3056
p.R13C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.3056
p.R13C	SIDM00793	Burkitt's Lymphoma	GDSC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.3056
p.R13C	SIDM00863	Burkitt's Lymphoma	GDSC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.3056
p.R13C	SIDM00808	Burkitt's Lymphoma	GDSC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation rewiring degron network	0.3056
p.S8L	SIDM00414	Bladder Carcinoma	GDSC	PETPNST	DEG_SCF_FBW7_1	6:12	Mutation altering degron motif	0.7667
p.P238S	ACH-000218	Leukemia	CCLE	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation rewiring degron network	0.0556
p.P238S	PL-21	haematopoietic and lymphoid tissue	COSMIC	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation rewiring degron network	0.0556
p.G222E	ACH-000395	Lung Cancer	CCLE	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation altering degron motif	0.6087
p.G222E	NCI-H520	lung	COSMIC	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation altering degron motif	0.6087
p.C230Y	ACH-000998	Colon/Colorectal Cancer	CCLE	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation rewiring degron network	0.2778
p.C230Y	CW-2	large intestine	COSMIC	DPGAEVVPN	DEG_SIAH_1	220:228	Mutation rewiring degron network	0.2778

Kaplan plot for DAZL in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DAZL

UniProt ID: Q92904

Entrez ID: 1618

Protein name: Deleted in azoospermia-like (DAZ homolog) (DAZ-like autosomal) (Deleted in azoospermia-like 1) (SPGY-like-autosomal)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DAZL in