DegronMD

Uniprot ID: Q92904

Source protein: Deleted in azoospermia-like

Source gene: DAZL

Class: DEG_SCF_FBW7_1

Location: 6:12

E3 ligase: FBXW7

DEGRON score: 0.9473

ASA_SCORE: 98.9571

COIL: 0.9397

CONS_SCORE: 0.373

DSS_SCORE: 0.7974

HELIX: 0.044

FCONS_SCORE: 0.9208

RIG_SCORE: 0.6297

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2V	TCGA-AP-A1DK	UCEC	TCGA	PETPNST	DEG_SCF_FBW7_1	0.6667
p.A2V	DO42033	UCEC	ICGC	PETPNST	DEG_SCF_FBW7_1	0.6667
p.A2V	DO41199	UCEC	ICGC	PETPNST	DEG_SCF_FBW7_1	0.6667
p.A4T	DO219084	BLCA	ICGC	PETPNST	DEG_SCF_FBW7_1	0.2778
p.T12A	DO230334	COCA	ICGC	PETPNST	DEG_SCF_FBW7_1	0.7139
p.T12A	DO229003	COCA	ICGC	PETPNST	DEG_SCF_FBW7_1	0.7139
p.T12A	DO229005	COCA	ICGC	PETPNST	DEG_SCF_FBW7_1	0.7139
p.T12A	DO234285	ESAD	ICGC	PETPNST	DEG_SCF_FBW7_1	0.7139
p.S5L	DO233867	GACA	ICGC	PETPNST	DEG_SCF_FBW7_1	0.3056
p.S5L	SIDM00049	Colorectal Carcinoma	GDSC	PETPNST	DEG_SCF_FBW7_1	0.3056
p.S5L	SIDM00179	Melanoma	GDSC	PETPNST	DEG_SCF_FBW7_1	0.3056
p.S5L	SIDM00176	Chondrosarcoma	GDSC	PETPNST	DEG_SCF_FBW7_1	0.3056
p.Q11L	DO228856	LICA	ICGC	PETPNST	DEG_SCF_FBW7_1	0.7765
p.L14M	DO229036	LICA	ICGC	PETPNST	DEG_SCF_FBW7_1	0.2778
p.P19L	DO229052	LICA	ICGC	PETPNST	DEG_SCF_FBW7_1	0.1389
p.T3A	DO229057	LICA	ICGC	PETPNST	DEG_SCF_FBW7_1	0.25
p.N10K	DO45161	LIRI	ICGC	PETPNST	DEG_SCF_FBW7_1	0.5806
p.R13H	SIDM00530	Esophageal Carcinoma	GDSC	PETPNST	DEG_SCF_FBW7_1	0.3056
p.F17L	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	PETPNST	DEG_SCF_FBW7_1	0.1944
p.R13C	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PETPNST	DEG_SCF_FBW7_1	0.3056
p.R13C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PETPNST	DEG_SCF_FBW7_1	0.3056
p.R13C	SIDM00793	Burkitt's Lymphoma	GDSC	PETPNST	DEG_SCF_FBW7_1	0.3056
p.R13C	SIDM00863	Burkitt's Lymphoma	GDSC	PETPNST	DEG_SCF_FBW7_1	0.3056
p.R13C	SIDM00808	Burkitt's Lymphoma	GDSC	PETPNST	DEG_SCF_FBW7_1	0.3056
p.S8L	SIDM00414	Bladder Carcinoma	GDSC	PETPNST	DEG_SCF_FBW7_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13117	Deleted in azoospermia protein 2	DEG_SCF_FBW7_1	6:12	PETPNST	FBXW7	0.6326	More...
Q86SG3	Deleted in azoospermia protein 4	DEG_SCF_FBW7_1	6:12	PETPNST	FBXW7	0.6326	More...
Q86SG3	Deleted in azoospermia protein 4	DEG_SCF_FBW7_1	171:177	PETPNST	FBXW7	0.8318	More...
Q92904	Deleted in azoospermia-like	DEG_SCF_FBW7_1	6:12	PETPNST	FBXW7	0.9473	More...
Q9NQZ3	Deleted in azoospermia protein 1	DEG_SCF_FBW7_1	6:12	PETPNST	FBXW7	0.7887	More...
Q9NQZ3	Deleted in azoospermia protein 1	DEG_SCF_FBW7_1	171:177	PETPNST	FBXW7	0.624	More...
Q9NQZ3	Deleted in azoospermia protein 1	DEG_SCF_FBW7_1	336:342	PETPNST	FBXW7	0.9674	More...
Q9NR90	Deleted in azoospermia protein 3	DEG_SCF_FBW7_1	6:12	PETPNST	FBXW7	0.9335	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons