DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PETPNST
Uniprot ID:
Q9NR90
Source protein:
Deleted in azoospermia protein 3
Source gene:
DAZ3
Class:
DEG_SCF_FBW7_1
Location:
6:12
E3 ligase:
FBXW7
DEGRON score:
0.9335
ASA_SCORE:
98.0571
COIL:
0.9424
CONS_SCORE:
0.3436
DSS_SCORE:
0.7537
HELIX:
0.0389
FCONS_SCORE:
1.0742
RIG_SCORE:
0.6293
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DAZ3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PETPNST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13117
Deleted in azoospermia protein 2
DEG_SCF_FBW7_1
6:12
PETPNST
FBXW7
0.6326
More...
Q86SG3
Deleted in azoospermia protein 4
DEG_SCF_FBW7_1
6:12
PETPNST
FBXW7
0.6326
More...
Q86SG3
Deleted in azoospermia protein 4
DEG_SCF_FBW7_1
171:177
PETPNST
FBXW7
0.8318
More...
Q92904
Deleted in azoospermia-like
DEG_SCF_FBW7_1
6:12
PETPNST
FBXW7
0.9473
More...
Q9NQZ3
Deleted in azoospermia protein 1
DEG_SCF_FBW7_1
6:12
PETPNST
FBXW7
0.7887
More...
Q9NQZ3
Deleted in azoospermia protein 1
DEG_SCF_FBW7_1
171:177
PETPNST
FBXW7
0.624
More...
Q9NQZ3
Deleted in azoospermia protein 1
DEG_SCF_FBW7_1
336:342
PETPNST
FBXW7
0.9674
More...
Q9NR90
Deleted in azoospermia protein 3
DEG_SCF_FBW7_1
6:12
PETPNST
FBXW7
0.9335
More...