DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PETPNST
Uniprot ID:
Q9NQZ3
Source protein:
Deleted in azoospermia protein 1
Source gene:
DAZ1
Class:
DEG_SCF_FBW7_1
Location:
336:342
E3 ligase:
FBXW7
DEGRON score:
0.9674
ASA_SCORE:
65.2143
COIL:
0.8449
CONS_SCORE:
0.3569
DSS_SCORE:
0.7007
HELIX:
0.078
FCONS_SCORE:
1.1036
RIG_SCORE:
0.6287
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DAZ1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PETPNST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13117
Deleted in azoospermia protein 2
DEG_SCF_FBW7_1
6:12
PETPNST
FBXW7
0.6326
More...
Q86SG3
Deleted in azoospermia protein 4
DEG_SCF_FBW7_1
6:12
PETPNST
FBXW7
0.6326
More...
Q86SG3
Deleted in azoospermia protein 4
DEG_SCF_FBW7_1
171:177
PETPNST
FBXW7
0.8318
More...
Q92904
Deleted in azoospermia-like
DEG_SCF_FBW7_1
6:12
PETPNST
FBXW7
0.9473
More...
Q9NQZ3
Deleted in azoospermia protein 1
DEG_SCF_FBW7_1
6:12
PETPNST
FBXW7
0.7887
More...
Q9NQZ3
Deleted in azoospermia protein 1
DEG_SCF_FBW7_1
171:177
PETPNST
FBXW7
0.624
More...
Q9NQZ3
Deleted in azoospermia protein 1
DEG_SCF_FBW7_1
336:342
PETPNST
FBXW7
0.9674
More...
Q9NR90
Deleted in azoospermia protein 3
DEG_SCF_FBW7_1
6:12
PETPNST
FBXW7
0.9335
More...