DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DPIDEYTTVP
Uniprot ID:
Q99715
Source protein:
Collagen alpha-1
Source gene:
COL12A1
Class:
CBL_PTK
Location:
2065:2074
E3 ligase:
CBL
DEGRON score:
0.7963
ASA_SCORE:
74.17
COIL:
0.4262
CONS_SCORE:
0.5637
DSS_SCORE:
0.4149
HELIX:
0.006
FCONS_SCORE:
1.1208
RIG_SCORE:
0.7859
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R2056M
TCGA-BF-A1Q0
SKCM
TCGA
DPIDEYTTVP
CBL_PTK
0.0833
p.R2056M
TCGA-BR-4184
STAD
TCGA
DPIDEYTTVP
CBL_PTK
0.0833
p.R2056M
DO47374
SKCM
ICGC
DPIDEYTTVP
CBL_PTK
0.0833
p.R2056M
DO38328
STAD
ICGC
DPIDEYTTVP
CBL_PTK
0.0833
p.I2081T
TCGA-CG-5722
STAD
TCGA
DPIDEYTTVP
CBL_PTK
0.1389
p.I2081T
DO38244
STAD
ICGC
DPIDEYTTVP
CBL_PTK
0.1389
p.P2061S
DO224944
BRCA
ICGC
DPIDEYTTVP
CBL_PTK
0.2222
p.I2081V
DO50332
ESAD
ICGC
DPIDEYTTVP
CBL_PTK
0.1389
p.P2074S
DO234170
ESAD
ICGC
DPIDEYTTVP
CBL_PTK
0.6752
p.P2061H
DO234393
ESAD
ICGC
DPIDEYTTVP
CBL_PTK
0.2222
p.P2061H
ACH-001973
Metastasis
CCLE
DPIDEYTTVP
CBL_PTK
0.2222
p.Q2083E
DO233064
GACA
ICGC
DPIDEYTTVP
CBL_PTK
0.0833
p.I2067V
DO27885
ORCA
ICGC
DPIDEYTTVP
CBL_PTK
0.5965
p.I2067V
SIDM01739
Small Cell Lung Carcinoma
GDSC
DPIDEYTTVP
CBL_PTK
0.5965
p.D2068Y
DO229227
THCA
ICGC
DPIDEYTTVP
CBL_PTK
0.6214
p.G2064V
SIDM00761
Small Cell Lung Carcinoma
GDSC
DPIDEYTTVP
CBL_PTK
0.3056
p.G2064V
ACH-000752
Lung Cancer
CCLE
DPIDEYTTVP
CBL_PTK
0.3056
p.G2064V
ACH-000966
Ovarian Cancer
CCLE
DPIDEYTTVP
CBL_PTK
0.3056
p.G2064V
NCI-H196
lung
COSMIC
DPIDEYTTVP
CBL_PTK
0.3056
p.G2064C
SIDM00761
Small Cell Lung Carcinoma
GDSC
DPIDEYTTVP
CBL_PTK
0.3056
p.G2064C
ACH-000752
Lung Cancer
CCLE
DPIDEYTTVP
CBL_PTK
0.3056
p.G2064C
ACH-000966
Ovarian Cancer
CCLE
DPIDEYTTVP
CBL_PTK
0.3056
p.G2064C
NCI-H196
lung
COSMIC
DPIDEYTTVP
CBL_PTK
0.3056
p.G2075V
ACH-000712
Lung Cancer
CCLE
DPIDEYTTVP
CBL_PTK
0.3056
Drug responses associated with COL12A1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DPIDEYTTVP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q99715
Collagen alpha-1
CBL_PTK
2065:2074
DPIDEYTTVP
CBL
0.7963
More...