DegronMD

Uniprot ID: Q9H2S9

Source protein: Zinc finger protein Eos

Source gene: IKZF4

Class: DEG_COP1_1

Location: 33:42

E3 ligase: COP1

DEGRON score: 0.9979

ASA_SCORE: 62.15

COIL: 0.841

CONS_SCORE: 0.3527

DSS_SCORE: 0.6168

HELIX: 0.0808

FCONS_SCORE: 1.1201

RIG_SCORE: 0.6777

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S35L	DO223072	ESCA	ICGC	DPSGGCVPDF	DEG_COP1_1	0.7667
p.P40L	TCGA-D1-A1O7	UCEC	TCGA	DPSGGCVPDF	DEG_COP1_1	0.7582
p.P40L	DO41139	UCEC	ICGC	DPSGGCVPDF	DEG_COP1_1	0.7582
p.V39A	SIDM00845	Burkitt's Lymphoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.6936
p.V39A	SIDM01519	Head and Neck Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.6936
p.V39A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DPSGGCVPDF	DEG_COP1_1	0.6936
p.P38S	ACH-000750	Skin Cancer	CCLE	DPSGGCVPDF	DEG_COP1_1	0.6752
p.P38S	LOXIMVI	skin	COSMIC	DPSGGCVPDF	DEG_COP1_1	0.6752
p.P34L	SIDM00845	Burkitt's Lymphoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.6471
p.P34L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DPSGGCVPDF	DEG_COP1_1	0.6471
p.G37E	DO233823	GACA	ICGC	DPSGGCVPDF	DEG_COP1_1	0.6087
p.F42V	DO234303	ESAD	ICGC	DPSGGCVPDF	DEG_COP1_1	0.5957
p.D33E	SIDM00845	Burkitt's Lymphoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.5647
p.D33E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DPSGGCVPDF	DEG_COP1_1	0.5647
p.P44S	TCGA-FW-A3R5	SKCM	TCGA	DPSGGCVPDF	DEG_COP1_1	0.2778
p.P44S	DO37406	SKCM	ICGC	DPSGGCVPDF	DEG_COP1_1	0.2778
p.Q45R	TCGA-VQ-A8PX	STAD	TCGA	DPSGGCVPDF	DEG_COP1_1	0.25
p.Q45R	DO51778	STAD	ICGC	DPSGGCVPDF	DEG_COP1_1	0.25
p.G28R	DO233089	GACA	ICGC	DPSGGCVPDF	DEG_COP1_1	0.1944
p.G28R	DO233757	GACA	ICGC	DPSGGCVPDF	DEG_COP1_1	0.1944
p.D48E	TCGA-23-1124	OV	TCGA	DPSGGCVPDF	DEG_COP1_1	0.1667
p.D48E	TCGA-AZ-6600	COAD	TCGA	DPSGGCVPDF	DEG_COP1_1	0.1667
p.D48E	DO10774	COAD	ICGC	DPSGGCVPDF	DEG_COP1_1	0.1667
p.D48E	DO32596	OV	ICGC	DPSGGCVPDF	DEG_COP1_1	0.1667
p.L49R	DO43306	UCEC	ICGC	DPSGGCVPDF	DEG_COP1_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2S9	Zinc finger protein Eos	DEG_COP1_1	33:42	DPSGGCVPDF	COP1	0.9979	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons