DegronMD

Uniprot ID: Q9H2S9

Source protein: Zinc finger protein Eos

Source gene: IKZF4

Class: DEG_COP1_1

Location: 33:42

E3 ligase: COP1

DEGRON score: 0.9979

ASA_SCORE: 62.15

COIL: 0.841

CONS_SCORE: 0.3527

DSS_SCORE: 0.6168

HELIX: 0.0808

FCONS_SCORE: 1.1201

RIG_SCORE: 0.6777

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D48E	TCGA-23-1124	OV	TCGA	DPSGGCVPDF	DEG_COP1_1	0.1667
p.D48E	TCGA-AZ-6600	COAD	TCGA	DPSGGCVPDF	DEG_COP1_1	0.1667
p.D48E	DO10774	COAD	ICGC	DPSGGCVPDF	DEG_COP1_1	0.1667
p.D48E	DO32596	OV	ICGC	DPSGGCVPDF	DEG_COP1_1	0.1667
p.P40L	TCGA-D1-A1O7	UCEC	TCGA	DPSGGCVPDF	DEG_COP1_1	0.7582
p.P40L	DO41139	UCEC	ICGC	DPSGGCVPDF	DEG_COP1_1	0.7582
p.P44S	TCGA-FW-A3R5	SKCM	TCGA	DPSGGCVPDF	DEG_COP1_1	0.2778
p.P44S	DO37406	SKCM	ICGC	DPSGGCVPDF	DEG_COP1_1	0.2778
p.Q45R	TCGA-VQ-A8PX	STAD	TCGA	DPSGGCVPDF	DEG_COP1_1	0.25
p.Q45R	DO51778	STAD	ICGC	DPSGGCVPDF	DEG_COP1_1	0.25
p.E25D	DO2665	BRCA	ICGC	DPSGGCVPDF	DEG_COP1_1	0.1111
p.R24W	DO222842	COCA	ICGC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.F42V	DO234303	ESAD	ICGC	DPSGGCVPDF	DEG_COP1_1	0.5957
p.S35L	DO223072	ESCA	ICGC	DPSGGCVPDF	DEG_COP1_1	0.7667
p.G28R	DO233089	GACA	ICGC	DPSGGCVPDF	DEG_COP1_1	0.1944
p.G28R	DO233757	GACA	ICGC	DPSGGCVPDF	DEG_COP1_1	0.1944
p.Q25L	DO233270	GACA	ICGC	DPSGGCVPDF	DEG_COP1_1	0.1111
p.G37E	DO233823	GACA	ICGC	DPSGGCVPDF	DEG_COP1_1	0.6087
p.R24L	DO229019	LICA	ICGC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.L49R	DO43306	UCEC	ICGC	DPSGGCVPDF	DEG_COP1_1	0.1389
p.R24Q	SIDM00662	Melanoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00623	Other Blood Cancers	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00803	Kidney Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00472	Ovarian Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00507	Other Solid Cancers	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00881	Breast Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00094	Kidney Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00346	Chronic Myelogenous Leukemia	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00148	Breast Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00730	Small Cell Lung Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00943	Pancreatic Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM01140	Ovarian Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00975	Melanoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00100	Mesothelioma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM00209	Glioblastoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.R24Q	SIDM01525	Acute Myeloid Leukemia	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0833
p.D33E	SIDM00845	Burkitt's Lymphoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.5647
p.D33E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DPSGGCVPDF	DEG_COP1_1	0.5647
p.P34L	SIDM00845	Burkitt's Lymphoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.6471
p.P34L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DPSGGCVPDF	DEG_COP1_1	0.6471
p.V39A	SIDM00845	Burkitt's Lymphoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.6936
p.V39A	SIDM01519	Head and Neck Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.6936
p.V39A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DPSGGCVPDF	DEG_COP1_1	0.6936
p.H23Y	SIDM00475	Ovarian Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	0.0556
p.P38S	ACH-000750	Skin Cancer	CCLE	DPSGGCVPDF	DEG_COP1_1	0.6752
p.P38S	LOXIMVI	skin	COSMIC	DPSGGCVPDF	DEG_COP1_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DPSGGCVPDF

Degron related mutations and impact score

Drug responses associated with IKZF4 mutations

All proteins holding degron of DPSGGCVPDF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2S9	Zinc finger protein Eos	DEG_COP1_1	33:42	DPSGGCVPDF	COP1	0.9979	More...