DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DPSSYSDAP
Uniprot ID:
O60828
Source protein:
Polyglutamine-binding protein 1
Source gene:
PQBP1
Class:
CBL_PTK
Location:
205:213
E3 ligase:
CBL
DEGRON score:
0.9989
ASA_SCORE:
66.5444
COIL:
0.8374
CONS_SCORE:
0.7576
DSS_SCORE:
0.634
HELIX:
0.1231
FCONS_SCORE:
1.1723
RIG_SCORE:
0.6215
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T216M
TCGA-2W-A8YY
CESC
TCGA
DPSSYSDAP
CBL_PTK
0.25
p.T216M
DO223732
CESC
ICGC
DPSSYSDAP
CBL_PTK
0.25
p.R196Q
TCGA-BR-8680
STAD
TCGA
DPSSYSDAP
CBL_PTK
0.0833
p.R196Q
TCGA-EO-A22U
UCEC
TCGA
DPSSYSDAP
CBL_PTK
0.0833
p.R196Q
DO47769
STAD
ICGC
DPSSYSDAP
CBL_PTK
0.0833
p.R196Q
DO43755
UCEC
ICGC
DPSSYSDAP
CBL_PTK
0.0833
p.P222S
DO228963
LICA
ICGC
DPSSYSDAP
CBL_PTK
0.0833
p.Y209H
DO231618
LINC
ICGC
DPSSYSDAP
CBL_PTK
0.834
p.S208L
DO222708
MELA
ICGC
DPSSYSDAP
CBL_PTK
0.6556
p.A212T
SIDM01268
Colorectal Carcinoma
GDSC
DPSSYSDAP
CBL_PTK
0.6028
Drug responses associated with PQBP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DPSSYSDAP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60828
Polyglutamine-binding protein 1
CBL_PTK
205:213
DPSSYSDAP
CBL
0.9989
More...
