DegronMD - O60828(PQBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T216M	TCGA-2W-A8YY	CESC	TCGA	DPSSYSDAP	CBL_PTK	205:213	Mutation rewiring degron network	0.25
p.T216M	DO223732	CESC	ICGC	DPSSYSDAP	CBL_PTK	205:213	Mutation rewiring degron network	0.25
p.E31K	TCGA-43-A475	LUSC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0556
p.E31K	TCGA-BR-8487	STAD	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0556
p.E31K	DO45431	LUSC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0556
p.E31K	DO47867	STAD	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0556
p.R196Q	TCGA-BR-8680	STAD	TCGA	DPSSYSDAP	CBL_PTK	205:213	Mutation rewiring degron network	0.0833
p.R196Q	TCGA-EO-A22U	UCEC	TCGA	DPSSYSDAP	CBL_PTK	205:213	Mutation rewiring degron network	0.0833
p.R196Q	DO47769	STAD	ICGC	DPSSYSDAP	CBL_PTK	205:213	Mutation rewiring degron network	0.0833
p.R196Q	DO43755	UCEC	ICGC	DPSSYSDAP	CBL_PTK	205:213	Mutation rewiring degron network	0.0833
p.E21D	TCGA-BS-A0UF	UCEC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.5647
p.E21D	DO41488	UCEC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.5647
p.L20M	TCGA-BS-A0UV	UCEC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.5999
p.L20M	DO42793	UCEC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.5999
p.E27D	TCGA-E6-A1LX	UCEC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1667
p.E27D	DO41020	UCEC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1667
p.P4H	TCGA-EE-A3AC	SKCM	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0833
p.P4H	DO37631	SKCM	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0833
p.A30V	TCGA-EO-A22U	UCEC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0833
p.A30V	DO43755	UCEC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0833
p.R10H	TCGA-FI-A2D5	UCEC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.25
p.R10H	DO41331	UCEC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.25
p.E27Q	TCGA-JW-A5VL	CESC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1667
p.E27Q	DO49976	CESC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1667
p.E21K	TCGA-L5-A8NT	ESCA	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.591
p.P222S	DO228963	LICA	ICGC	DPSSYSDAP	CBL_PTK	205:213	Mutation rewiring degron network	0.0833
p.Y209H	DO231618	LINC	ICGC	DPSSYSDAP	CBL_PTK	205:213	Mutation altering degron motif	0.834
p.S208L	DO222708	MELA	ICGC	DPSSYSDAP	CBL_PTK	205:213	Mutation altering degron motif	0.6556
p.A212T	SIDM01268	Colorectal Carcinoma	GDSC	DPSSYSDAP	CBL_PTK	205:213	Mutation altering degron motif	0.6028
p.A12T	ACH-002664	Colon/Colorectal Cancer	CCLE	KRGILKHLE	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.3056

Kaplan plot for PQBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PQBP1

UniProt ID: O60828

Entrez ID: 10084

Protein name: Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PQBP1 in